George Cross, the Head of the Molecular Parasitology Department at the Rockefeller University, states that these DNA sequences, released recently, are so very different from those of human beings, that it would be a matter of ease to discover suitable drugs to fight them with, and this is indeed excellent good news for the thousands of sufferers of such diseases, all over the world. An important fact to remember is that the tritryps need nutrients from their hosts, without which they cannot survive, being parasites. This means that they cannot manufacture sialic acid, which is the sugar that these parasites need in order to develop the complex surface molecules that they make so that they can escape the human immune response. (Parsing Parasites: genomes of three tropical parasites are sequenced) This bit of information was made evident only because the scientists were able to discover the DNA sequencing of these parasites, and in addition, it will be based on this information that scientists will be able to, in the future, devise suitable dugs which would be able to effectively block pathways such as the sialic acid uptake, and then kill the parasites.
If I were an impoverished citizen of the world, living in extremely dire circumstances, then I would most definitely like to see an end to the diseases that are rampant among my people, and the fact that research is being conducted that would effectively find a treatment and a cure for the deadly diseases that threaten my very existence gives me a great surge of hope, and I feel that pharmaceutical companies must take more interest in developing drugs that would fight deadly parasitic diseases. Although it is a fact that work has indeed been started in this regard and scientists have indeed been able to make a great breakthrough in being able to decipher the DNA sequencing of certain deadly parasites, it must be said that there is a lot of work yet to be done, before therapies and novel treatments can be developed which would be of use to the common man who may become afflicted with such killer diseases at any point of his life.
For example, if a...
RESULTS The first noticeable result was at first disappointing but turned around later in the trail. At first the rsaL mutation did not have any effect on the production of 30C12-HSL nor on lasl transcription, but it began to appear later in the logarithmic phase of propagation at which time the 30C12-HSL production along with Plasl activity reached homoeostasis in the wild strain while continuing to increase rsaL in the mutant
Molecular Basis Glanzmann Thrombasthenia An investigation of the molecular basis of Glanzmann Thrombasthenia using Polymerase Chain Reaction (PCR) The objective of this project is to investigate the molecular basis of Glanzmann Thrombasthenia (GT) using polymerase chain reaction. There have been many mutations discovered in GT patients over the years in many studies. Thus using PCR to genotype patients is one of the most effective ways of discerning the genetic basis of the
Expression Profiling of a Novel Protein A new transcription unit was discovered while working with transfected murine BAC clones, because a novel spot appeared on a 2-dimensional protein gel. Through a process of expression subcloning from the BAC clone, the transcription unit that generated the novel peptide was located. This finding was back validated by sequencing the protein contained in the 2-D gel piece using N-terminal Edman degradation and mass spectroscopy
Nanomachines The Science of molecular size machines and its engineering designs and constructions until late 1980s were not considered practicable. Nanotechnology, according to the leading exponents of that time were neither feasible nor viable, due to the fact of total structural difference of the constituent of nano-molecular device i.e. Atoms from the mechanical objects of every day life. The essential components of engineering mechanics i.e. cogwheels, gears or motors could not
laboratory-based practical work undertaken in this module was in relation to a case study of Systemic Lupus Erythematosus, SLE. SLE is a connective tissue disorder, which is autoimmune in nature. This disease affects multiple organs and its clinical manifestation is based on its severity and the organ involved. The pathogenesis of this disease is based on antigen-antibody complexes that circulate in the blood and deposit in the smaller blood
The failure of human hamster fusion in the presence of anti-human izumo antibody clearly showed that Human izumo protein is essential for fertilization. This study however has raised some new questions. The difference in fertilization capacities between wild type and Izumo +/- type was not clearly discussed. Also, the fact that ICSI of izumo -/- produces twice as many litters as did the izumo +/- type implicates the possible role
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