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Lamictal: The Oral Anticonvulsant And Essay

There are certain interactions that may cause toxicity Administration

The drug may be administered orally without regard to meals.

Overdose

The seriousness of an overdose of Lamictal depends on the ingested amount. There are however several non-life threatening symptoms of overdosing Lamictal with symptoms raging from ataxia, dizziness, somnolence and headache. However, in certain cases of overdose, the patient would experience renal and liver failure, delirium, rash as well as coma. The lethal dosage is lower for children. All suspected cases of Lamictal overdose should be treated as a medical emergency and the patient should be taken for immediate medical attention.

Conclusion

Lamictal has been very effective in the treatment and management of epilepsy and depression. A review of literature however suggests that it has certain risks in its administration. It is therefore necessary to be careful when taking or prescribing this medication. There are reports that the drug Seroquel by Astrazeneca would overtake it in the treatment of depression (PR Newswire,2007)

References

GlaxoSmithKline (2004). LAMICTAL®(lamotrigine) Tablets

http://www.mentalmeds.org/prescription_meds/Lamictal.pdf

Lamotrigine.(1993)A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 1993;46:152-76
Keck, P., and McElroy, S (2003) New Approaches in Managing Bipolar Depression. J Clin Psychiatry 2003;64 (suppl 1).

http://www.psychiatrist.com/pcc/pccpdf/v05s01/v64s0103.pdf

Motte J, Trevathan E, Arvidsson JFV, et al. (1997)Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J. Med;337:1807-12.

Ohman I, Vitols S, and Tomson T.(2000) Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41:709-13

PR Newswire (2007). AstraZeneca's Seroquel Will Overtake GlaxoSmithKline's Lamictal

by 2010 as the Gold Standard for the Treatment of Bipolar Depression.

http://www.prnewswire.com/news-releases/astrazenecas-seroquel-will-overtake-glaxosmithklines-lamictal-by-2010-as-the-gold-standard-for-the-treatment-of-bipolar-depression-58016677.html

Thase, M.E. And Denko, T (2008), Pharmacotherapy of Mood Disorders. Annual Review of Clinical Psychology, Vol. 4, April 2008.

Sources used in this document:
References

GlaxoSmithKline (2004). LAMICTAL®(lamotrigine) Tablets

http://www.mentalmeds.org/prescription_meds/Lamictal.pdf

Goa KL, Ross SR, Chrisp P. Lamotrigine.(1993)A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 1993;46:152-76

Keck, P., and McElroy, S (2003) New Approaches in Managing Bipolar Depression. J Clin Psychiatry 2003;64 (suppl 1).
http://www.psychiatrist.com/pcc/pccpdf/v05s01/v64s0103.pdf
http://www.prnewswire.com/news-releases/astrazenecas-seroquel-will-overtake-glaxosmithklines-lamictal-by-2010-as-the-gold-standard-for-the-treatment-of-bipolar-depression-58016677.html
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