There are certain interactions that may cause toxicity
Administration
The drug may be administered orally without regard to meals.
Overdose
The seriousness of an overdose of Lamictal depends on the ingested amount. There are however several non-life threatening symptoms of overdosing Lamictal with symptoms raging from ataxia, dizziness, somnolence and headache. However, in certain cases of overdose, the patient would experience renal and liver failure, delirium, rash as well as coma. The lethal dosage is lower for children. All suspected cases of Lamictal overdose should be treated as a medical emergency and the patient should be taken for immediate medical attention.
Conclusion
Lamictal has been very effective in the treatment and management of epilepsy and depression. A review of literature however suggests that it has certain risks in its administration. It is therefore necessary to be careful when taking or prescribing this medication. There are reports that the drug Seroquel by Astrazeneca would overtake it in the treatment of depression (PR Newswire,2007)
References
GlaxoSmithKline (2004). LAMICTAL®(lamotrigine) Tablets
http://www.mentalmeds.org/prescription_meds/Lamictal.pdf
Keck, P., and McElroy, S (2003) New Approaches in Managing Bipolar Depression. J Clin Psychiatry 2003;64 (suppl 1).
http://www.psychiatrist.com/pcc/pccpdf/v05s01/v64s0103.pdf
Motte J, Trevathan E, Arvidsson JFV, et al. (1997)Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J. Med;337:1807-12.
Ohman I, Vitols S, and Tomson T.(2000) Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41:709-13
PR Newswire (2007). AstraZeneca's Seroquel Will Overtake GlaxoSmithKline's Lamictal
by 2010 as the Gold Standard for the Treatment of Bipolar Depression.
http://www.prnewswire.com/news-releases/astrazenecas-seroquel-will-overtake-glaxosmithklines-lamictal-by-2010-as-the-gold-standard-for-the-treatment-of-bipolar-depression-58016677.html
Thase, M.E. And Denko, T (2008), Pharmacotherapy of Mood Disorders. Annual Review of Clinical Psychology, Vol. 4, April 2008.
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