Verified Document

Deformities Of The Vertebral Column Essay

Related Topics:

¶ … defects that can affect the vertebral column, some clinically serious, others that can be corrected by surgery and still others that denigrates the affected individual's lifestyle to a high degree. Such deformities and maladies as spina bifada, scoliosis and chordoma can all be debilitating on the individual. Due to the complexity of the vertebral column, it is often difficult to diagnosis and treat many of the afflictions that present in many patents. One recent study determined that "due to the sporadic occurrence of congenital vertebral malformations, traditional linkage approaches to identify genes associated with human vertebral development are not possible" (Giampietro, Raggio, Reynolds, Shukla, McPherson, Ghebranious, Jacobsen, Kumar, Faciszeski, Pauli, Rasmussen, Burmester, Zaleski, Merchant, David, Weber, Glurich, Blank, 2005, p. 448). Of course, that particular study was conducted almost a decade ago and great strides have been made since that time, but it is still a very difficult maneuver to discover exactly what malformations are taking place in the vertebral column and decide on the appropriate treatment.

study attempted to discover was whether DNA sequencing could assist researchers in discovering how malformations took place and if any of the prevalent vertebral malformations were inherited traits. However, the study discovered that "our inability to reach a straightforward interpretation of our data illustrates the challenges of identifying the role of patterning genes in the pathogenesis of sporadic vertebral malformations" (Giampietro et al., p. 452).
One of the less common malformations in the vertebral column is the variation in the number of vertebrae which can be too many, or not enough. A good example of this type of scenario is a patient that is experiencing Klippel-Feil syndrome.

Discovered in the early 1900's, this syndrome takes place when any two of the seven cervical vertebrae experience congenital fusion. As one recent study determined, Klippel-Fiel syndrome is "characterized by the congenital fusion of any two of the seven cervical vertebrae and is often accompanied by Sprengel's deformity and existence of omovertebral bone"…

Sources used in this document:
Works Cited

Giampietro, P.F.; Raggio, C.L.; Reynolds, C.E.; Shukla, S.K.; McPherson, E.; Ghebranious, N.; Jacobsen, F.S.; Kumar, V.; Faciszewski, T.; Pauli, R.M.; Rasmussen, K.; Burmester, J.K.; Zaleski, C.; Merchant, S.; David, D.; Weber, J.L.; Glurich, I.; Blank, R.D.; (2005) An analysis of PAX1 in the development of vertebral malformations, Clinical Genetics, Vol. 68, Issue 5, pp. 448-453

Rosti, R.O.; (2013) Of mice, men, and King Tut: autosomal recessive Klippel-Feil syndrome is caused by mutations in MEOX1, Clinical Genetics, Vol. 84, Issue 1, pp. 19 -- 19
Cite this Document:
Copy Bibliography Citation

Related Documents

Quality of Life Among Tawau Hospital Sufering
Words: 8383 Length: 25 Document Type: Research Paper

Quality of Life Among Tawau Hospital Sufering From Knee Osteoarthritis With Physiotherapy Qualitative study of How Quality of Life of Tawau Hospital Staff Suffering from Knee Osteoarthritis have been improved at Physiotherapy Unit. To investigate how the Quality of Life among Tawau Hospital staff suffering from Osteoarthritis (knees) have been improved using Physiotherapy intervention. The study employs qualitative techniques to collect data. The sample population is selected from people and Tawau Hospital staff visiting the

Galectin-1 in the Regulation of
Words: 4060 Length: 14 Document Type: Introduction

The success was remarkable, according to the researchers: Even muscles that had already lost half of its mass, recovered visible. (Leppanen et al. p5549-65) At the same time, the mice survived for several weeks longer than their untreated counterparts and also developed a healthy appetite again. (Mantovani, p296) The new study is therefore interesting in two respects: First, it demonstrates that the muscle loss at least in animal models in

Marfan Syndromme Is a Multisystem
Words: 3574 Length: 13 Document Type: Term Paper

This became more so with the advancement of molecular Biology Tests. Subsequently a group of clinicians met in Ghent Belgium and came up with the current diagnostic criteria known as the Ghent Nosology. (De Paepe et al. 1996) Similar to the Berlin Nosology the Ghent criteria was based on clinical findings in the various organ systems as well as the nature of family history and relationships, a major criteria

Sign Up for Unlimited Study Help

Our semester plans gives you unlimited, unrestricted access to our entire library of resources —writing tools, guides, example essays, tutorials, class notes, and more.

Get Started Now