Database Presentation
The objective of this study is to present a new database to be implemented in the clinical setting to increase quality and safety of patient care.
The database at focus in this work in writing is that of the Targeted Therapy Database (TTD) in a Cancer unit in a hospital. The work of Mocellin, et al. (2010) relates that the "efficacy of current anticancer treatments is far from satisfactory and many patients still die of their disease. A general agreement exists on the urgency of developing molecularly targeted therapies, although their implementation in the clinical setting is in its infancy. In fact, despite the wealth of preclinical studies addressing these issues, the difficulty of testing each targeted therapy hypothesis in the clinical arena represents an intrinsic obstacle. As a consequence, we are witnessing a paradoxical situation where most hypotheses about the molecular and cellular biology of cancer remain clinically untested and therefore do not translate into a therapeutic benefit for patients." (p.1) According to Mocellin (2010) Cancer is representative of the "third leading cause of death throughout the world and second in Western countries. However, early diagnosis is the best possible way of cure for the majority of types of cancer. Targeted therapy is reported to include "those approaches that aim to tailor the therapy to the patient (or cohort of patients) based on specific molecular features of the disease- and/or patient. The ultimate goal is obviously to maximize the therapeutic efficacy while minimizing the toxicity, that is, increasing the therapeutic index. In cancer medicine, tumor-specific molecular derangements (e.g., gene mutation or protein overactivation), are the ideal targets for therapeutic strategies aimed to kill malignant cells while sparing normal cells. Furthermore, patient-specific molecular features such as polymorphisms of detoxifying enzymes can affect the metabolism of anticancer drugs and thus can play a role in both efficacy and toxicity profiles. According to these principles, personalized targeted therapy includes not only the development and clinical implementation of "smart" drugs (i.e., agents that target tumor-specific molecular derangements), but also the identification of the patient molecular profile that maximizes the therapeutic index of "conventional" chemotherapeutics." (Mocellin, et al., 2010, p.1)
Two mainstreams of research in the field of targeted anticancer therapy are those stated as follows:
(1) to develop novel therapeutic...
" "STUDENT INFORMATION TABLE" ( "STUDENT ID" CHARACTER (4) NOT NULL, NAME CHARACTER (25) NOT NULL, "STREET NUMBER" CHARACTER (10) NOT NULL, "STREET NAME" CHARACTER (25) NOT NULL, CITY CHARACTER (25) NOT NULL, STATE CHARACTER (10) NOT NULL, EMAIL CHARACTER (25) NOT NULL, "PHONE NUMBER" CHARACTER (15) NOT NULL ); CONNECT RESET; SQL FOR Book_Information CONNECT TO LIBRARY; CREATE TABLE "USER"; CREATE TABLE BookInformation ( "BookISBN" CHARACTER (10) NOT NULL; "AUTHOR" CHARACTER (25) NOT NULL; "TITLE" CHARACTER (50) NOT NULL; "PRICE" CHARACTER (10) NOT NULL; CONNECT RESET; SQL STATEMENT FOR
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