However, an individual should be able to investigate their own roots, even if the science is questionable. hen such information is released into the public domain without the individual's permission though, a lot of harm can be done. Making invasions into a person's genetic history illegal is probably the best remedy.
Genetic testing has become an important tool for medical diagnosis and treatments (Norrgard) and therefore should be available to anyone needing or requesting such services. hat is done with this information, however, is another matter. Family members may suspect they have an increased risk for an early onset or even fatal disease, but would prefer not to know if effective treatments and cures are unavailable. Should one family member decide to get tested, then this may create friction between family members concerning their wishes and personal privacy because the results would have an impact on everyone in the family.
Genetic…...
mlaWorks Cited
Norrgard, K. "Ethics of Genetic Testing: Medical Insurance and Genetic Discrimination." Nature Education 1.1 (2008). Web. 3 May 2013.
Abbott, a. "Genome Test Slammed for Assessing Racial Purity." Nature 486 (2012):167.
Genetic counseling involves the sharing vital information and knowledge by experienced and well trained experts in the field of genetics for individuals with high risks of suffering some genetic disorders or transferring it to their children. It is the responsibility of a genetic counselor to provide relevant information concerning the hereditary nature of certain diseases and their risks of reoccurrence; addresses the concerns of patients, their health care providers and their families; and lends assistance to both the patients suffering these hereditary ailments and their families.
The first genetic counseling center was the Hereditary Clinic established at the University of Michigan in the United States in 1940. Since then, several such centers have been established in different parts of the world.
Through genetic counseling, information is made available to give the needed support to people who are dealing with any genetic disorder or at risk of developing one. When dealing with a…...
mlaReferences
Brickell, K., Steinbart, E., Rumbaugh, M., Payami, H., Schellenberg, G., Deerlin, V. V.,... Bird, T. (2006). Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease. Arch Neurol, 63(9), 1307-11.
Campion, D., Dumanchin, C., Hannequin, D., Dubois, B., Belliard, S., Puel, M.,... Frebourg, T. (1999). Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J. Hum Genet, 65(3), 664-70.
CDC. (2015, March 3). Genetic Counselling. Retrieved from U.S. Department of Health & Human Services: http://www.cdc.gov/ncbddd/genetics/genetic_counseling.html
Goldman, J. S., MS, M., Hahn, S. E., Catania, J. W., Larusse-Eckert, S., Butson, M. B.,... Bird, T. (2011). Genetic counseling and testing for Alzheimer disease: Joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med, 13(6), 597 -- 605.
Designing Babies: Genetic Engineering
The rapid development of science and technology has led to an advanced knowledge in the human genome with an increasing ability to change and modify genes to assist people designing babies that suit their wishes in the future. The genetic screening techniques are already being used in some countries where embryos are selected by sex and genes resistance to diseases. The argument in support of genetic engineering is that in the future, scientists will have the ability to replace the faulty genes with healthy DNA genes thereby eradicating the genetic diseases. Through genetic engineering it will be possible to design babies who will be highly intelligent, becoming great leaders and scientists in the future. Additionally, it will be possible to correct genetic diseases passed from generation to generation assisting families to install genes that offer lifelong protection against diseases. Despite the aforementioned benefits suggested by the scientists,…...
mlaWorks Cited
Mill J. S. On Liberty[1859], In Utilitarianism, on liberty, considerations on representative government. London: Everyman.
Parker, M. "The best possible child." Journal of Medical Ethics 33.5 (2007): 279-83. Web.
Regalado, Antonio. "Engineering the Perfect Baby." MIT Technology Review (2015).
Lo, Bernard and Parham, Lindsay. Ethical Issues in Stem Cell Research. Endocr Rev 30.3 (2007): 204 -- 213.
Huntington's disease (HD) was the first autonomic dominant disorder for which genetic prediction became possible" (Harper, et al., 2000, Journal of Medical Genetics, p. 567). HD is a disease that occurs due to an inherited disorder leading to the death of brain cells. A diagnosis of HD is accomplished through genetic testing which can be implemented at any age regardless of whether the symptoms manifest or not. Although, the specific symptoms vary between people, nevertheless, symptoms can start with people between 35 and 45 years of age and can also start in some individuals at even anearlier age. The disease may affect successive generations if health interventions are not implemented (Mandel, 2016).
Additionally, "the cause of HD is due to a dominant mutation of autosomal form of the gene called Huntington. This shows that a child born by an affected person has a 50% chance of developing or inheriting the disease"…...
mlaReferences
Causes and risk factors. (2016). Health Communities. Retrieved from healthcommunities.com/huntingtons-disease/cause.shtml.http://www.
Denbo, S. M. (2013, January 1). Balancing the rights of children, parents and the state: The legal, ethical and psychological implications of genetic testing in children. Southern Journal of Business and Ethics, 5, 188-190.
Domaradzki, J. (2015, January 1). Lay constructions of genetic risk. A case-study of the Polish Society of Huntington's Disease. Polish Sociological Review, 189, 107-111.
Draper, B. (2004). Dealing with dementia: A Guide to Alzheimer's Disease and other dementias. Crows Nest, NSW: Allen & Unwin.
Nursing and Genetics
As noted by Lea (et al.) "Obtaining a family history is an established and familiar screening activity used by nurses and other healthcare providers across many healthcare settings" (Lea 2010:4). However, the increased commonality of doing a genetic profile on patients has made gathering such a family history far more revelatory than ever before. Nurses must gain a better understanding of how genetics affects patient health in a very specific fashion to be effective healthcare providers in the future. Nurses are "ideally situated" to inform patients about what genetic information means, given the patient-centered focus of the profession (Lea 2011: 3). Nurses must understand the implications of genetic testing to comprehend the extent to which a disease is likely to manifest itself in a patient. Patients must be able to realistically evaluate the threats they face.
At present, "genetic tests are offered to those suspected of having a genetic…...
mlaReferences
Conley, Y. & Tinkle, M. (2006). The future of genomic nursing research. Journal of Nursing
Scholarship, 38: 213-218
Lea, DH (et al. 2011). Implications for educating the next generation of nurses on genetics and genomics in the 21st century. Journal of Nursing Scholarship, 43:1, 3 -- 12.
Lea, DH (2006). U.S. genetics nurses in advanced practice. Journal of Nursing Scholarship,
DIECT-TO-CONSUME GENETIC TESTING 1Direct-to-Consumer Genetic TestingDirect-to-consumer genetic testing is a consumer-centric form of genetic testing in which a customer procures a test from an online store by just learning of it via advertisements on the internet, television, print media, or in-store (Oh, 2019). The customer purchases testing kits from the company, collects their DNA sample according to instructions on the sheet, sends the sample to the company, and receives their results via a secure website (Oh, 2019). One of the most popular DTC genetic testing websites is 23andMe (https://www.23andme.com/?fd=dr), which markets itself as a comprehensive provider of ancestry, traits, and health genetic testing services.DTC testing provides avenues for customers to assess their genetic predisposition to certain phenotypes, such as diseases, which allows them to take proactive health improvement steps (Oh, 2019). Further, DTC testing is easily accessible, faster, and less expensive as it does not require a clinicians approval (Oh,…...
mlaReferences Flowers, E., Leutwyler, H., & Shim, J. (2020). Direct-to-Consumer Genomic Testing. Nursing, 50(8), 48-52. Doi: 10.1097/01.NURSE.0000684200.71662.09Oh, B. (2019). Direct-to-Consumer Genetic Testing: Advantages and Pitfalls. Genomics & Informatics, 17(3), Doi: 10.5808/GI.2019.17.3.e33
Genetic Influence of MDMA Neurotoxicity
MDMA Neurotoxicity
Ecstasy [(±)-3.4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is one of the most popular drugs of abuse in the world (Capela et al., 2009, p. 211). Often used in social settings, such as the so-called 'raves' or all night dance parties, ecstasy has been reported to lower barriers to intimacy, increase the pleasure derived from friendships, enhance social interactions, and increase energy (euphoria) (Peters and Kok, 2009, p. 242).
In the U.S., MDMA is classified as a schedule 1 drug due its addictive potential, lack of therapeutic utility, dubious safety profile, and neurotoxic potential (Capela et al., 2009, p. 212) and its use has been illegal since 1985. The safety concerns of MDMA include the potential for a negative therapeutic outcome (Parrott, 2007) and its neurotoxicity (Capela et al., 2009). Apparently, the use of MDMA in a psychotherapy setting can produce a negative outcome that can persist for…...
mlaReferences
Capela, Joao P., Carmo, Helena, Remiao, Fernando, Bastos, Maria L., Meisel, Andreas, and Carvalho, F. (2009). Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: An overview. Molecular Neurobiology, 39, 210-271.
Carmo, Helena, Brulport, Marc, Hermes, Matthias, Oesch, Franz, Silva, Renata, Ferreira, Luisa M. et al. (2006). Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine ('ecstasy') cytotoxicity. Pharmakogenetics and Genomics, 16, 789-799.
Esse, Katherine, Fossati-Bellani, Marco, Traylor, Angela, and Martin-Schild, Sheryl. (2011). Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard. Brain and Behavior, 1, 44-54.
Parrott, A.C. (2007). The psychotherapeutic potential of MDMA (3.4-methylenedioxymethamphetamine): An evidence-based review. Psychopharmacology, 191, 181-93.
" This category of identifiers, is however, weak. There are apparently a list of indicators such as name and address that have to be removed from the database in order to use the DNA evidence without notifying the person. When these markers are removed, the evidence is considered public. Yet there are potentials for those markers to resurface and privacy can never be ensured. Even though Angrist is in favor of a public pool of DNA evidence for the lofty goals of science, he agrees, "de-identification is increasingly difficult." It is becoming hard to disconnect names, dates, and places from the hemoglobin and NA. Science appreciates access to DNA because it can link certain traits with others and thereby advance scientific knowledge.
Although it is important to protect a person's privacy regarding DNA, it is too difficult to do so given the rampant greed in the biomedical industry and the collusion…...
mlaReferences
Angrist, Misha. "Genetic privacy needs a more nuanced approach." Nature. 6 Feb, 2013. Retrieved online: http://www.nature.com/news/genetic-privacy-needs-a-more-nuanced-approach-1.12363
Nature. "Genetic Privacy." 17 Jan 2013. Retrieved online: http://www.nature.com/news/genetic-privacy-1.12238
The Washington Times. "Editorial: Preserving Genetic Privacy." The Washington Times. 21 Feb, 2013. Retrieved online: http://www.washingtontimes.com/news/2013/feb/21/preserving-genetic-privacy/
Genetic screening is one of the most controversial topics in the scientific arena today. The advent of the Human Genome Project, which maps the complete human genetic code, has brought this issue to the forefront. This paper will discuss the basic science that underlies genetic screening, applications of genetic screening, and investigate some of the common misconceptions and ethical questions about its use.
Genetic screening itself is simply "the systematic search within a population for persons possessing particular genotypes, which are either associated with disease, predisposing to disease, or leading to disease in descendants" (Miller). In simpler terms, genetic screening involves testing and determining whether "an individual's genetic material to predict present or future disability or disease either for oneself or one's offspring" (McCarrick). Essentially, genetic screening is conducted for several basic reasons, including the care of the ill and the prevention of disease, providing reproductive information, determining the incidence of…...
mlaWorks Cited
Alberts, Bruce. 2002. Molecular biology of the cell, 4th ed. New York: Garland Science.
Genetic Science Learning Center. 2004. Genetic Disorder Corner. University of Utah. 07 May 2004. http://gslc.genetics.utah.edu/units/disorders/
McCarrick, Pat Milmoe. 1993.Genetic Testing and Genetic Screening. Scope Note 22. National Reference Center for Bioethics Literature, Georgetown University, 1993. Kennedy Institute of Ethics Journal (KIEJ), Reprinted September 1993, 17 p. (Last updated February 2002). 07 May 2004. http://www.georgetown.edu/research/nrcbl/scopenotes/sn22.html
Miller, Kelly. 1999. Genetic Screening. Phil McClean, Professor, Ph.D. Colorado State University, PLSC 431/631 - Intermediate Genetics. 07 May 2004. The mundane by excellent cinematography and an effective cast.http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/students99/miller.htm.
, 2006). He visualized and described the malignancy process. He suggested that early that "cells of tumors with unlimited growth" would develop with the elimination of chromosomes, which inhibit the growth. The multiple genetic alterations in these inhibiting chromosomes are today known as TSGs. The theory supposes that cancer arises from functional defect or absence of one or more TSGs. Clinical trials of TSG gene replacement therapy for breast cancer include the viral wild-type p53, Rb, and mda7. Molecular chemotherapy involves the introduction of suicide genes. The concept evolved from the assumption that cancer cells could be made more sensitive to chemotherapeutics or toxins by introducing "suicide genes." It was a concept initiated in the late 80s. Suicide gene therapy is categorized into toxin gene therapy and enzyme-activating pro-drug therapy. Suicide gene therapy is also called gene-directed enzyme pro-drug therapy or GDEPT. GDEPT treatment consists of the delivery of the…...
mlaBIBLIOGRAPHY
Abaan, O. D and Criss, Wayne E (2002). Gene therapy in human breast cancer. 32
(2002): 283-291 Turkey Journal of Medical Science: Tubitak. Retrieved on April 15,
2010 from http://journals.tubitak.gov.tr/medical/issues/sag-02-32-4-1-0204.pdf
Lowery, A.J., et al. (2009). MicroRNA signatures predict oestrogen receptor,
"Accurate descriptions of sex chromosome differences are critical, the decisions potentially regrettable, and the long-term outcomes devastating if a termination is based on the misinformation," that the patient later discovers to be misinformation for instance, "that any of these conditions is comparable to Down's Syndrome" (Biesecker r 2001:2) Conversely, it is also important not to minimize the odds of a potentially fatal genetic condition like Tay Sachs disease.
Providers are obliged to obtain useful up-to-date information and to ensure parents have adequate opportunity to consider their decision with the help of an experienced healthcare provider, preferably in medical genetics, and if necessary, a counselor who is attuned to the cultural assumptions and needs of the couple's population group, and religious beliefs. Certain populations might have a different view and understanding of the real difficulty of raising a child suffering from a heritable disorder, or even the concept of heritability of…...
mlaWorks Cited
Baker, Schuette & Uhlmann. (Eds.) (1998). A guide to genetic counseling.
Beery, Theresa a & Kerry a. Schooner. (Nov 2004). "Family History: The First Genetic
Screen." Nurse Practioner. Retrieved 23 Jun 2007 at http://findarticles.com/p/articles/mi_qa3958/is_200411/ai_n9469874/pg_5
Biesecker, Barbara. (24 Feb 2001). "Prenatal diagnoses of sex chromosome conditions:
Newspaper Opinion Editorial
With advances in genetic studies, Canadians can learn if they are at risk of developing devastating diseases -- and so can their insurance companies. Genetic discrimination is growing as an increasing number of people are opting for genetic tests, including people at risk of developing Huntington's disease, a degenerative brain disorder that cannot presently be cured or slowed. Children of parents with Huntington's disease have a 50% chance of developing the disorder, and genetic testing can narrow the probability ratio even further.
Genetic discrimination is unfair and the result of faulty, speculative thinking. Genetic discrimination is misleading also misleading as it is based on probability prediction, which can be absolutely incorrect. Genetic discrimination is defined as "the differential treatment of asymptomatic individuals or their relatives on the basis of their real or assumed genetic characteristics. Consider that for many individuals whose parents do have Huntington's disease, only 50% will…...
mlaSources:
Ethical Issues in Genetic Testing. (2008, June). Number 410. The American Congress of Obstetricians and Gynecologists [Web]. Retrieved http://www.acog.org/
Resources%20And%20Publications/Committee%20Opinios/Committee%20on%20Ethics/Ethical%20Issues%20in%20Genetic%20Testing.aspx
CTV.ca News Staff (2009, June 9). Some Canadians suffering 'genetic discrimination.' Bell Media. Retrieved http://www.ctvnews.ca/some-canadians-suffering-genetic-discrimination-1.406308
Lapman, E.V., Kozma, C. And Weiss, J. (1996, October 25). Science, 274. Genetic discrimination: Perspectives of consumers.
Heather D's decision not to be tested for the Huntington's gene a wise one?
Heather D's decision not to be tested for Huntington's is unwise given that Heather is about to become a mother. If she develops the disease, this could significantly impair her ability to parent a child. She should make provisions for the child if she has the mutation and should discuss the situation with her husband. The genetic test for Huntington's is not a test that merely indicates a tendency or a likelihood of developing the debilitating condition -- because of the fairly narrow chromosomal area affected by the mutation, scientists can predict with a great degree of certainty who will or who will not develop the disorder (579).
Q2. Does the genetic counselor's suggestion provide a satisfactory solution to the problem?
No. Most individuals who are opposed to abortion also view the termination of fertilized embryos outside of…...
Researchers at Cornell University discovered that Monarch butterfly caterpillars died when they ate plants dusted with the pollen of Bt corn that was growing in nearby fields, and many scientists worry that with so much insecticide in the corn plants, insects might develop a resistance to it (Dyer 2002). These fears and concerns are echoed by Francis Fukuyama who believes that genetic enhancement will undermine the system of human rights by disrupting the boundary that encloses all humans in a single group, thus believes society should limit genetic science to allow therapy but prohibit enhancement, such as genetically altered food crops, and non-therapeutic procedures (Tobey 2003). In other words, enhancement will allow society to increase genotypic and phenotypic diversity, yet such diversity will press society to the point of losing its shared humanity (Tobey 2003).
orks Cited
Adams, endy a. (2002, January 01). Reconciling private benefit and public risk in biotechnology:…...
mlaWelsh, Whitney. (2005, March 01). Brave new worlds: philosophy, politics, and science in human biotechnology. Population and Development Review. Retrieved July 09, 2005 from HighBeam Research Library Web site: http://www.highbeam.com/library/doc3.asp?DOCID=1G1:132710930&num
9&ctrlInfo=Round14%3AProd%3ASR%3AResult&ao=&FreePremium=BOTH
This article discusses the ethics and political landscape concerning genetic engineering, particularly the current White House administration. It includes some twenty references.
revolution in understanding genetic contributions to the susceptibility for developing particular diseases and disorders has been the development of the notion of "personalized medicine." The "personalized" connotation of this growing facet in the practice does not refer to individualized treatments as much as it refers to a personalizing of treatments targeted at a specific subset of patients, for example the development of certain drugs that can target specific cancer-causing genes found in patients' tumors. A drug currently being reviewed by the FDA for release is crizotinib, an anaplastic lymphoma kinase (ALK) inhibitor. ALK is believed to be active in several different types of tumors, including about five percent of non-small-cell lung carcinomas (NSCLC). In patients with advanced NSCLC it has been found that those carrying the echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) fusion gene possess a protein product of this fusion that contains a constitutive kinase activity…...
mlaReferences
Bang, Y., Kwak, E.L., Shaw, A.T. et al. (2010). Clinical activity of the oral ALK inhibitor PF- 02341066 in ALK-positive patients with nonsmall cell lung cancer (NSCLC). Journal of Clinical Oncology, 28 (18S), 3.
Christensen, J.G., Zou, H.Y., Arango, M.E., Li, Q., Lee, J.H., McDonnell, S.R., Yamazaki, S., Alton, G.R., Mroczkowski, B., & Los G. (2007). Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Molecular Cancer Therapy, 6, 3314-3322.
Ku, G.Y. & Lima Jopes Jr., G. (2011). EML4-ALK in non-small-cell lung cancer: the breathtaking progress from benchtop to Phase III clinical trial. Therapy, 8(1)55-61.
Kwak, E.L., Bang, Y.J., Camidge, D.R. et al. (2010). Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. New England Journal of Medicine, 263(18), 1693- 1703.
1. The impact of the Affordable Care Act (Obamacare) on access to healthcare in the United States
2. The effectiveness of Medicare and Medicaid in providing affordable healthcare to low-income and elderly populations
3. The future of universal healthcare in the United States
4. The role of pharmaceutical companies in rising healthcare costs
5. The importance of mental health coverage in healthcare policies
6. The debate over the privatization of healthcare services
7. The impact of electronic health records on patient care and privacy
8. The implications of genetic testing and personalized medicine on healthcare policy
9. The role of preventative care and public health initiatives in reducing....
1. Understanding the role of the CA4 gene in retinitis pigmentosa
2. The genetic basis of retinitis pigmentosa and the CA4 gene
3. Exploring the impact of CA4 gene mutations on retinal degeneration
4. The future of gene therapy for retinitis pigmentosa linked to the CA4 gene
5. Unraveling the molecular pathways of retinitis pigmentosa involving the CA4 gene
6. Genetic testing for CA4 gene mutations in patients with retinitis pigmentosa
7. Therapeutic strategies targeting the CA4 gene in retinitis pigmentosa treatment
8. CA4 gene as a potential biomarker for predicting progression of retinitis pigmentosa
9. Gene editing technologies for correcting mutations in the CA4 gene associated with....
Lesser-Known but Intriguing Essay Topics on Type 2 Diabetes
1. The Interplay between Gut Microbiota and Type 2 Diabetes
Explore the role of gut microorganisms in the development and progression of type 2 diabetes.
Discuss the potential for modulating gut microbiota as a therapeutic approach.
Examine the impact of diet, prebiotics, and probiotics on gut health in relation to type 2 diabetes.
2. Precision Medicine for Type 2 Diabetes Management
Analyze the application of genetic testing and biomarkers to personalize treatment strategies.
Discuss the role of pharmacogenomics in tailoring medication selection and dosage.
Explore the ethical and practical considerations of using precision....
I. Introduction
A. Brief overview of Down syndrome
B. Introduction to Down syndrome in Iceland
C. Thesis statement: The recent history of Down syndrome in Iceland has been shaped by advancements in genetic testing and a controversial screening program.
II. Genetic Testing in Iceland
A. Introduction to genetic testing
B. Advancements in genetic testing in Iceland
C. Impact on Down syndrome rates
D. Criticisms of genetic testing
III. Screening Program in Iceland
A. Introduction to screening programs
B. Overview of Iceland's controversial screening program
C. Ethical implications of the screening program
D. Public perception of the screening program
IV. Support for Individuals with....
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