Cognitive DevelopmentIn A Conversation with obert Sapolsky, the interviewee discusses the role that stress hormones play on neurons in the brain, and how they might affect the onset of Alzheimers or stress patients. His first goal in research is to understand this connection, and in his own words he states, I am trying to understand, on a cellular level, how one class of hormones released during stress can damage neurons, and what that has to do with which of us have lots of brain damage after a stroke or seizure, or who succumbs to Alzheimers (Brain Connection, n.d.). His focus is on that part of the brain used in learning and memory, and his aim is to see how stress impacts the nervous system.Once understanding that relationship between stress hormones and neurons in the brain, Sapolsky wants to focus on saving the neurons from damage due to stress-related factors. One…...
mlaReferencesBrain Connection. (n.d.). A conversation with Robert Sapolsky. Retrieved from https://brainconnection.brainhq.com/library/interviews/
Gonadectomy alters the magnitude of CCS and ICS analgesia and alters the relationship between the gender-specific effects observed in sham-treated rats. Castration significantly decreased the magnitude of CCS analgesia on the tail-flick and jump tests, and the magnitude of ICS analgesia on the jump test. Indeed castration reduced the magnitude of CCS and ICS analgesia in males to that observed for sham-treated female rats.
Conclusion
Given the multitude of CNS substrates and systems underlying both opioid and stress analgesia, and the likelihood that only a little differ amid sexes, we could rationally expect to come across sex differences in opioid analgesic efficacy in some occasions, depending solely on the nature of the ache incentive and opioid involved, as outlined earlier. It is important to also note that sex differences are no defined to opioid drugs in analgesia. Furthermore, commencement of endogenous pain inhibitory mechanisms in reaction to stress also produces magnitudes…...
mlaWorks Cited
Islam, Anita K., Madeline L. Cooper, and Richard J. Bodnar. "Interactions among Aging, Gender, and Gonadectomy Effects Upon Morphine Antinociception in Rats." Physiology and Behavior 54 (1993): 45-53. Print.
Romero, Maria-Teresa, et al. "Gender-Specific and Gonadectomy-Specific Effects Upon Swim Analgesia: Role of Steroid Replacement Therapy." Physiology and Behavior 44 (1988): 257-65. Print.
Romero, Maria-Teresa, et al. "Modulation of Gender-Specific Effects Upon Swim Analgesia in Gonadectomized Rats." Physiology and Behavior 40 (1987): 39-45. Print.
The circulatory or cardiovascular system is responsible for moving nutrients, wastes and gases between body cells, transporting blood across the whole body and battling disease (Circulatory System). Its principal elements are the heart, numerous blood vessels, and blood.
The heart forms the circulatory system's core. This 2-sided, 4-chambered pump which distributes blood to various arteries comprises of the right and left ventricles, and right and left atria. The ventricles, situated within the heart's lower half, are responsible for pumping blood to the whole body (away from our heart), whilst the atria, situated within the heart's upper half are in charge of receiving blood from different parts of the human body. The right and left ventricles pump de-oxygenated and oxygenated blood, respectively; de-oxygenated blood is pumped to lungs while oxygenated blood is pumped to the remainder of the human body (smith, 2013). These 4 chambers are connected to one another by means…...
Vestibular and Olfactory Sensory Systems
Static and Dynamic Equilibrium
Mechanisms of Vestibular-Mediated Equilibrium
There are two types of equilibrium that the vestibular system helps to maintain: static and dynamic (Virtual Medical Centre, 2010, para. 31). Static equilibrium provides feedback concerning head position or head movement when the body is stationary. In contrast, dynamic equilibrium involves sensing motion or acceleration/deceleration of the head. Acceleration can be further divided into sensing a change in linear velocity, either horizontally or vertically, and angular velocity associated with rotation of the head.
The vestibular system's contribution to maintaining equilibrium critically depends on inner ear structures. The saccule and utricle together provide sensory information concerning static equilibrium and linear acceleration, while the semicircular canals contribute information about angular acceleration (Virtual Medical Centre, 2010, para. 31-32). Both the saccule and utricle contain a small patch of hair cells and supporting cells, which are known as maculae. The saccule and utricle maculae…...
mlaReferences
Hain, T. And Helminski, J. (2001). Anatomy and physiology of the normal vestibular system. In S. Herdman (Ed.) Vestibular Rehabilitation, 3rd Edition (pp. 2-18). Philadelphia F.A. Davis Company.
Lledo, Peirre-Marie, Gheusi, Gilles, and Vincent, Jean-Didier. (2005). Information processing in the mammalian olfactory system. Physiological Reviews, 85, 281-317.
Virtual Medical Centre. (2010). Ear. VirtualMedicalCentre.com. Retrieved 12 Dec. 2011 from http://www.virtualmedicalcentre.com/anatomy/ear/29
Anatomy and Physiology of the Skeletal and Muscular SystemsIntroductionToday, human health is being threatened on multiple fronts and it is not surprising that there is growing interest in developing a better understanding about the human bodys various systems and the respective roles they play in maintaining good health. Some people may intuitively recognize the importance of the skeletal and muscular systems to human health, but far too few understand the fundamental anatomy and physiology of these systems. In response to this constraint, the purpose of this paper is to provide a discussion concerning the anatomy and physiology of the skeletal and muscular systems in the human body as well as selected associated disorders that are associated with those systems. Following this review, a summary of the findings is provided in the conclusion.The Skeletal System1. AnatomyIt is important to note that although the human skeletal system is widely regarded as a…...
mlaReferencesAbdelgawad, A. A. et al. (2013, September). Submuscular Bridge Plating for Complex Pediatric Femur Fractures Is Reliable. Clinical Orthopaedics and Related Research, 471(9), 2797-2807.Anatomy of the Joints. (2007). Arthritis, 2–5.Cowen, P. T. & Kahai, P. (2022). Anatomy, bones. In: StatPearls. Treasure Island, FL: StatPearls Publishing.Docherty, B. (2007). Skeletal system. Part three--The axial skeleton and Part four--the appendicular skeleton. Nursing Times, 103(7), 26–27.Human skeletal system. (2022). ACLS Training Center. Retrieved from human-skeletal-system.Riancho, J., Delgado, A. M., Andreu, M. D., Paz, F. L., Arozamena, S., Gil, B. F. J., & López de Munaín, A. (2021). Amyotrophic lateral sclerosis (ALS), cancer, autoimmunity and metabolic disorders: An unsolved tantalizing challenge. British Journal of Pharmacology, 178(6), 1269–1278.Robertson, B. (2015). Q: What Do We Mean by Structure and Function in Science? Science & Children, 52(7), 92.Smeets, J. S. J., Horstman, A. M. H., Vles, G. F., Emans, P. J., Goessens, J. P. B., Gijsen, A. P., van Kranenburg, J. M. X., & van Loon, L. J. C. (2019). Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans. PloS One, 14(11), e0224745.https://www.acls.net/
An interesting view of the immune system with particular implications for the current review and collation of information is provided by the field of computer science. The immune system makes many series of continual trade-offs, distributing resources in a way that necessarily leaves certain vulnerabilities in the system as a whole while providing greater comprehensiveness in coverage and protection when necessary (Hofmeyr 1997). This makes the immune system an adaptive and continually evolving and self-improving system; with little outside direction it is capable of assessing changing needs, and altering itself not only in particular instances but even in some of its general responses in order to provide greater long-term efficacy for the task of protecting the human organism from disease (Hofmeyr 1997). This view of the immune system as a contained and self-informing system is not entirely accurate, but it is a very useful perspective for our purposes herein.
The Nervous…...
mlaReferences
Buske-Kirschbaum, a. (2009). "Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response." Neuroimmunomodulation 16, pp. 325-32.
Coe, C. & Laudenslager, M. (2007). "Psychosocial influences on immunity, including effects on immune maturation and senescence." Brain, behavior, and immunity 21(8), pp. 1000-8.
Dugdale, D. (2008). "Immune response -- overview." University of Maryland medical center. Accessed 22 May 2010. http://www.umm.edu/ency/article/000821.htm
Dunigan, J.; Carr, B. & Steel, J. (2007). "Posttraumatic Growth, Immunity and Survival in Patients with Hepatoma." Digestive diseases and sciences 52(9), pp. 2452-9.
Psychology
The nervous system is a part of an animal's body which is responsible for the coordination of voluntary and involuntary actions as well as the transmission of signals between different parts of the body. It is responsible for sending, receiving and the processing of nerve impulses all over the body. All the organs and muscles within the body rely upon the nerve impulses in order for them to function. The nervous system receives information from sense organs regarding the environment by means such as hearing, sight, smell, pressure, taste and pain. The nervous system consists of tow main parts; the central nervous system and the peripheral nervous system. The central nervous system comprises of the brain and the spinal cord. It is surrounded by the bone-skull and the vertebrae. The peripheral nervous system comprises of numerous neurons which are its functional units. The central nervous system is responsible for…...
mlaReferences
Farr, G. (2002). The Nervous System - Advanced Version / What is the Nervous System?. Become healthy now. Retrieved 6, September 2014 from http://www.becomehealthynow.com/article/bodynervousadvanced/826
Powell, K. (2014). Nature vs. Nurture . about parenting. Retrieved 6, September 2014 from http://genealogy.about.com/cs/geneticgenealogy/a/nature_nurture.htm
1968).
Fetal Alcohol Syndrome is clearly a debilitating, serious, and devastating disease that affects not only prenatal fetuses, but developing children, teenagers, and adults, as well as their families, and society in general. While more research is needed to discover possible medications, surgery, or other choices for those already born with FAS, the only solution to the problem is education for pregnant women on the dangers of alcohol consumption on the life of their unborn child. Women addicted to alcohol should seek immediate assistance during pregnancy to avoid causing lifelong damage to their child, and those not addicted should abstain from alcohol consumption during pregnancy. It is only through abstinence that FAS can be extinguished.
eferences
Aase, J.M., 1981, "The fetal alcohol syndrome in American Indians: A high risk group," Neurobehavioral Toxicology and Teratology, vol. 3, no. 2, p. 153-156.
Abel, E.L. & Sokol, .J., 1986, "Fetal alcohol syndrome is now leading cause…...
mlaReferences
Aase, J.M., 1981, "The fetal alcohol syndrome in American Indians: A high risk group," Neurobehavioral Toxicology and Teratology, vol. 3, no. 2, p. 153-156.
Abel, E.L. & Sokol, R.J., 1986, "Fetal alcohol syndrome is now leading cause of mental retardation," Lancet, vol. 2, p. 1222.
Abel, E.L. & Sokol, R.J., 1987, "Incidence of fetal alcohol syndrome and economic impact of Fetal Alcohol Syndrome-related anomalies," Drug and Alcohol Dependence, vol. 19, p. 51-70.
CDC, 2005, "CDC issues guidelines for identification of fetal alcohol syndrome," MMWR Morbid Mortal Weekly Report, vol. 54, no. 11, p. 1-15.
eshaping the Sensory Environment
Sensory Accuracy
Survival of all animals depends on the accuracy with which sensory information is processed by the nervous system. Integrating this information in an efficient and effective manner depends on dynamic strategies that the nervous system relies on to determine the reliability and accuracy of the sensory inputs (reviewed by Zaidel, Turner, and Angelaki, 2011). This essay examines contemporary theories that attempt to explain how these strategies function.
eliability-Based Cue Combination (BCC) Theory
The reliability of a sensory cue is believed to determine the weight an organism assigns to a given cue, such that a more reliable cue may have a greater influence on behavioral outcomes (reviewed by Zaidel, Turner, and Angelaki, 2011). Empirical support for this theory has come from studies examining the integration of multisensory information. This theory has been called reliability-based cue combination (BCC).
eliability, as defined by BCC, is used interchangeably for sensory precision; however, these…...
mlaReferences
Bestmann, S., Oliviero, A., Voss, M., Dechent, P., Lopez-Dolado, E., Driver, J. et al. (2006). Cortical correlates of TMS-induced phantom hand movements revealed with concurrent TMS-fMRI. Neuropsychologia, 44, 2959-2971.
Burge, Johannes, Girshick, Ahna R., and Banks, Martin S. (2010). Visual-haptic adaptation is determined by relative reliability. Journal of Neuroscience, 30, 7714-7721.
Scarfe, Peter and Hibbard, Paul B. (2011). Statistically optimal integration of biased sensory estimates. Journal of Vision, 11, 1-17. Retrieved 13 Apr. 2012 from www.journalofvision.org/content/11/7/12.
Winter, J.A., Allen, T.J., and Proske, U. (2005). Muscle spindle signals combine with the sense of effort to indicate limb position. Journal of Physiology, 568, 1035-1046.
Von Hippel-Lindau
Von Hippel Lindau Disease
Von Hippel-Lindau Disease
Von Hippel-Lindau Disease
Von Hippel-Lindau Disease
The von Hippel-Lindau, also known by its synonyms, familial angiomatosis cerebeloretinal, hemangioblastomatosis or retinal and cerebellar angiofacomatosis, is the abnormal growth of retinal- cerebellar vessels, and is classified as a rare disease of autosomal dominant hereditary character, within the group of phacomatosis. The disease was described by two independent groups, led by Eugen von Hippel (1904) and Arvid Lindau (1927). The cause of the disease is the mutation of both alleles of the VHL group, the one caused by genetic factors, and the second after a de novo mutation. The von Hippel-Lindau syndrome is considered by increased tendency to kidney tumors, central nervous system, including the cerebellum, and by affecting the retina. At the moment, no medical treatment is present for curing this disease, but knowledge of their symptoms and possible genetic research currently makes it possible to establish early…...
mlaReferences
He's FJ, Hoppener JW, Lips CJ (2003). Clinical review 155: pheochromocytoma in Von Hippel-Lindau disease. J Clin Endocrinol Metab; 88: 969 -- 974.
Johnston LB, Chew SL, Trainer PJ, Reznek R, Grossman AB, Besser GM, Monson JP, Savage MO (2000). Screening children at risk of developing inherited endocrine neoplasia syndromes. Clin Endocrinol (Oxf); 52: 127 -- 136.
Lindau A (1927). On the question of angiomatosis retinae and your brain complicatio. Acta Ophthalmol; 4: 193 -- 226.
Lonser R, Glenn G, Walther M, Chew EY, Libutti SK, Linehan WM, et al. (2003). Von Hippel-Lindau disease. Lancet;361:2059-67.
Pharmaceutical industries have to operate in an environment that is highly competitive and subject to a wide variety of internal and external constraints. In recent times, there has been an increasing trend to reduce the cost of operation while competing with other companies that manufacture products that treat similar afflictions and ailments. The complexities in drug research and development and regulations have created an industry that is subject to intense pressure to perform. The amount of capital investment investments required to get a drug from conception, through clinical trials and into the market is enormous. The already high-strung pharmaceutical industry is increasingly investing greater amounts of resources in search of the next "blockbuster" drug that can help them gain market position and profits. Laws, regulations and patents are important to the industry while spending billions of dollars in ensuring the copyright of their products.
It is the intention of this thesis…...
mlaBibliography
Ansoff, H.I. (1957). Strategies for diversification. Harvard Business Review, 35(5), 113-124.
Ansoff, H.I. (1965). Corporate Strategy. New York, NY: McGraw-Hill.
Ashour, M.F., Obeidat, O., Barakat, H., & Tamimi, A. (2004). UAE Begins Examination of Patent Applications. Tamino.com. Retrieved January 18, 2004, from the World Wide Web: http://www.tamimi.com/lawupdate/2001-01/intprop.htm
Bain, J.S. (1954). Economies of scale, concentration, and the condition of entry in twenty manufacturing industries. American Economic Review, 44, 15-36.
When watching a scary movie alone at night, this system is likely to become engaged due to the perception of a threat; sudden noises are likely to cause an involuntary flight reaction that, of course, subsides after a moment.
8)
Temporal summation in a nerve cell occurs when the length of time over which successive activation potentials occur is sufficiently long enough to allow for the potentials to continue to the point where they begin to overlap. When this occurs, a new activation starts to begin before the climax of the preceding action potential has been reached. This action potential essentially ends prematurely, or summates, as it begins the rise into the next action potential, which ends up being larger in magnitude than the constituent action potentials. Summation of active potential in muscle fibers allows for similarly larger action potentials, which can increase the strength of the fiber contractions.
9)
There are two…...
Teenager's Brain
A Teenagers Brain
The teenage brain is different from the normal adult's brain in which "…various parts of the brain work together to evaluate choices, make decisions and act accordingly in each situation." (Edmonds, 2010) The teenage brain can be compared to an entertainment center, according to Edmonds "that hasn't been fully hooked up. There are loose wires, so that the speaker system isn't working with the DVD players, which in turn hasn't been formatted to work with the television yet. And to top it all off, the remote control hasn't even arrived." (2010)
Brain Development
Edmonds (2010) explains that the remote control for the brain is the 'prefrontal cortex' described as "a section of the brain that weighs outcomes, forms judgments, and controls impulses and emotions. This section of the brain also helps people understand one another." (Edmonds, 2010) Synapses are used by the prefrontal cortex in communicating with other…...
mlaReferences
Edmonds, M. (2010) Are Teenage Brains Really Different From Adult Brains? Discovery Health. Brain and Central Nervous System. Retrieved from: http://health.howstuffworks.com/human-body/systems/nervous-system/teenage-brain2.htm
Adolescent Brain Development (2002) ACT for Youth -- Upstate Center of Excellence. Cornell University, University of Rochester and the NYS Center for School Safety. May 2002. Research Facts and Findings. Retrieved from: http://www.actforyouth.net/documents/may02factsheetadolbraindev.pdf
Sohn, Emily (2005) Teen Brains, Under Construction. Science News. 28 Sept 2005. Retrieved from: http://www.sciencenewsforkids.org/articles/20050928/Feature1.asp
Winters, KC and McLellan, AT (2008) Adolescent Brain Development and Drug Abuse. Jan 2008. TRI Science Addiction (Treatment Research Institute) Philadelphia PA Retrieved from: http://www.tresearch.org/archives/2008Jan_TeenBrain.pdf
Psychoactive Substance Use and Abuse
A psychoactive substance refers to any chemical which both impacts the central nervous system and the way the brain functions. Psychoactive substances refer to stimulants (cocaine, methamphetamine, dextroamphetamine), sedatives and analgesics (alcohol, heroin), hallucinogens (PCP, psychoactive mushrooms). As stated in the DSM-III "psychoactive substance abuse is given the definition of being "a maladaptive pattern of use indicated by continued use despite knowledge of having a persistent or recurrent social, occupational, psychological or physical problem that is caused by the use [or by] recurrent use in situations in which it is physically hazardous" (Nordegren, 2002, p.11).
Social Effects
The social impact of psychoactive substance use and abuse on widespread scale is enormously detrimental to society. "In a 2005 report issued by the Department of Health and Human Services indicated that alcohol was associated with 100,000 preventable deaths each year and that it cost taxpayers nearly $185 billion annually" (Lundy…...
mlaReferences
Aspen. (2011). The Impact of Trauma On Teenage Addiction. Retrieved from Crchealth.com: http://aspeneducation.crchealth.com/articles/article-trauma/
Becvar, D. (2013). Handbook of Family Resilience. New York: Springer Science Publishing.
Dennison, S. (2011). Handbook of the Dually Diagnosed Patient: Psychiatric and Substance Use. Philadelphia: Lippincott Williams and Wilkins.
Dick, D., & Agrawai, A. (2008). The Genetics of Alcohol and Other Drug Dependence. Alcohol Research and Health, 111-118.
Anatomy: Parkinson's Disease
Parkinson's disease is a central nervous system disease that is degenerative. It disrupts normal functioning at the cellular level by reducing the activity of cells that secret dopamine (Davie, 109). That happens through the death of cells, as well, in a couple of different regions of the brain. The two regions most affected are both related to movement and learning. They also affect how a person reacts to something, and whether he or she feels like a particular behavior was rewarding. The pathways that connect the basal ganglia of the brain to other areas are all affected in people who have Parkinson's disease (Shulman, De Jager, & Feany, 196). The symptoms are based on the ways in which those pathways are disrupted by the disease process and the death of the cells. As these cells die, they are not able to stop the body's systems from activating at…...
mlaWorks Cited
Davie, C.A. "A review of Parkinson's disease." British Medical Bulletin, 86(1): 109 -- 127. 2008. Print.
Shulman, J.M., De Jager, P.L., & Feany, M.B. "Parkinson's disease: Genetics and pathogenesis." Annual review of pathology, 6: 193 -- 222. 2011. Print.
Maternal alcohol consumption during pregnancy can have damaging effects on fetal development and lead to fetal alcohol syndrome (FAS). When a pregnant woman consumes alcohol, it crosses the placenta and enters the developing fetus's bloodstream, affecting its growth and development in various ways:
1. Alcohol interferes with the delivery of nutrients and oxygen to the fetus, leading to growth restrictions and low birth weight.
2. Alcohol exposure can disrupt the development of the fetus's brain and central nervous system, resulting in cognitive and behavioral impairments, learning disabilities, and developmental delays.
3. Alcohol can cause structural abnormalities in the fetus's facial features, such as....
Chandipura Virus: A Significant Threat to Human Health
Introduction
Chandipura virus (CHPV) is a mosquito-borne alphavirus that belongs to the Togaviridae family. It was first isolated in 1965 from a deceased forest worker in Chandipura, India. CHPV has a wide geographic distribution, spanning from Southeast Asia to Africa. The virus causes a wide range of clinical manifestations, from mild fever to severe encephalitis. Due to its potential for causing neurological complications and its high mortality rate, CHPV poses a significant threat to human health.
Clinical Manifestations
CHPV infection typically presents with a febrile illness characterized by fever, malaise, headache, and muscle pain. In some....
1. Plants have developed a fascinating array of chemical defenses to protect themselves from various threats such as herbivores, pathogens, and environmental stressors. These chemical compounds not only play a crucial role in the survival of plants but also have the potential to benefit human health through their unique properties. Researchers have increasingly turned their attention to exploring the therapeutic potential of plant chemical defenses in medical treatments and therapies. By harnessing the power of these natural compounds, scientists aim to develop new drugs, supplements, and therapies that could effectively combat various diseases and improve human health.
2. One way....
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