Ethics of Stem Cell esearch
Stem Cell esearch Ethics

The Ethics of Stem Cell esearch: A Nursing Perspective

The Ethics of Stem Cell esearch: A Nursing Perspective

When the world-famous cloned sheep, Dolly, was euthanized at the relatively young age of 6-1/2 years she was suffering from advanced aging and lung disease (Meek, 2003). In human years, Dolly was only about 40-years old and had been suffering from arthritis for many years. This outcome is consistent with the claims of some scientists that current cloning technology does not accurately replicate natural sexual reproduction and disproportionately generates debilitating and sometimes lethal genetic defects. Dolly was the product of somatic cell nuclear transfer (SCNT), which involved removing the DNA from a sheep somatic (adult) cell, inserting it into an egg, and then transferring the egg to a receptive womb. This technology is very similar to what is currently being developed by stem cell researchers, especially the…...

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References

ANA. (2007). American Nurses Association Position Statement on Stem Cell Research. Retrieved 13 Mar. 2014 from http://gm6.nursingworld.org/MainMenuCategories/EthicsStandards/Ethics-Position-Statements/StemCellResearch.txt.

ANA. (2009). ANA comments on stem cell research. Retrieved 13 Mar. 2014 from  http://nursingworld.org/FunctionalMenuCategories/MediaResources/PressReleases/2009-PR/ANA-on-Stem-Cell-research.pdf .

Armstrong, A.E. (2006). Towards a strong virtue ethics for nursing practice. Nursing Philosophy, 7, 110-124.

Arnason, V. (2010). Bioethics in Iceland. Cambridge Quarterly of Healthcare Ethics, 19(3), 299-309.

Analysts agree that Proposition 71 will at least pay for itself over the life of the bonds.
According to Somers (2004): "The economists from Stanford University and the Analysis Group predict that the initiative would generate at least $6.4 billion. They say it would generate $2.2 billion to $4.4 billion if it could expand the state's biotechnology industry by about 5%, with new jobs, construction of new buildings and increased revenue. If the research could reduce health care spending by 1% to 2%, the direct savings in health care costs to the state government would be $3.4 billion to $6.9 billion, on just the care and treatment of patients suffering from six of the medical conditions scientists think could benefit from new stem-cell therapies."

Still, there is no guarantee that life saving, cost-saving therapies will be found (Somers, 2004). Even if they are, scientists say it is many years away. Therefore,…...

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References

Associated Press. (November 4, 2004). Californians approve stem cell research funding. USA Today. Retrieved from the Internet at  http://www.usatoday.com/news/politicselections/vote2004/2004-11-02-ca-initiative-stem-cell_x.htm .

Cahill, Lisa Sowle. (2001). Stem Cells: A Bioethical Balancing Act." America 184.10: 14-19.

Friedrich, MJ. (2000). Debating Pros and Cons of Stem Cell Research.JAMA 284.6 (2000): 681-82.

Honolulu Advertiser. (October 27, 2004). Stem cell research is worth exploring. Honolulu Advertiser. Retrieved from the Internet at  http://the.honoluluadvertiser.com/article/2004/Oct/27/op/op02p.html .

Limitations of Stem Cell esearch
The primary objection to stem cell research in the United States is based on the belief that commonly held social, moral, and ethical boundaries will be breached in the effort to ensure adequate supplies of embryonic stem cells (Hoffman, et al., 2004; eeves, 2001) Because of the potential medical and economic implications of stem cell research, executive level governmental decisions have been made regarding acceptable limits for stem cell research (Hoffman, et al., 2004; eeves, 2001) These limits have changed as the national executive leadership has changed (Hoffman, et al., 2004; eeves, 2001) Presidents have issued Executive Orders regarding stem cell research that reflect their personal beliefs and the beliefs expressed by voices dominating the American press at any given time (Hoffman, et al., 2004; eeves, 2001) epresentation of stem cell researchers and those who potentially would benefit from stem cell research have been less well…...

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References

2006 Ballot Measure: Constitutional Amendment 2: Stem Cell Initiative, submitted October 11, 2005. Retrieved http://www.sos.mo.gov

Ertelt, S. (2009, March 2). IPS Cells, An Embryonic Stem Cell Research Alternative, Make Major Advance, LifeNews. Retrieved  http://www.lifenews.com/ 

Gretchen Vogel (2008, September 26). A New, Improved Stem Cell Recipe. ScienceNOW. Retrieved  http://sciencenow.sciencemag.org/ 

Hoffman, D.I., et al. (2003, May). Cryopreserved embryos in the United States and their availability for research. Fertility and Sterility, 79 (5). Accessed at: How many frozen human embryos are available for research? Law & Health Initiative, (2003). Retrieved  http://www.rand.org

Even paralysis such as from diving and motor vehicle accidents will probably be able to be cured by stem cell applications (Sagan, 1997).
Legal and Ethical Issues:

Despite their tremendous potential for benefiting human health and welfare, many oppose the use of fetal stem cells because of their religious beliefs. According to many

Christians in particular, both abortion and the use of any fetal tissue for medical purposes is immoral because human life begins at conception (Dershowitz, 2002; Levine, 2007).

According to this view, even the embryos produced in-vitro fertilization clinics must not be used for research purposes, even with the consent of the patients who donated the sperm and egg.

The previous presidential administration of George Bush outlawed the federal funding of any stem cell research of this (most valuable) type in 2001 and, as a result, the United States has lost years of tremendously important research in that area (Kinsley,

2007; Pollack, 2007).…...

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Works Cited

Dershowitz, A.M. (2002). Shouting Fire: Civil Liberties in a Turbulent Age. New

York: Little Brown & Co.

Kinsley, M. (2007). "Commentary: Why Science Can't Save the GOP" Time (Dec.

10/07: 36).

The ban needs to be used to prevent the sale of embryos, use of cloning and the production of embryos for the sole purpose of research. Cures for debilitating diseases will hopefully result and healing is supposed to be the driving factor in medicine. It is a poor argument to talk of murder, destruction and disrespect of human life when the United States continues to utilize capital punishment, the legal murder of a human being for purposes of criminal punishment. This type of dichotomy results in irrational or illogical positions in contrast to developing a truer position. In addition, legal issues are at stake and the fact that abortion is legal in the United States should be a critical part of the discussion. Since personal choice is the key to legal abortions, it seems that the same person can and should be allowed to consent to medical research following…...

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References

Fumento, M. (n.d.). Michael Fumento: Embryonic Research Driven by Greed, not Science. Michael Fumento.com. Retrieved November 11, 2010, from  http://www.fumento.com/biotech/greatstemcell.html 

Guenin, L. (n.d.). ISSCR:: Public: Perspective: Ethics of Human Embryonic Stem Cell Research . International Society for Stem Cell Research. Retrieved November 11, 2010, from  http://www.isscr.org/public/ethics.htm 

Guidelines for Human Embryonic Stem Cell Research. (n.d.). The National Academies Press. Retrieved November 11, 2010, from  http://www.nap.edu/openbook.php?record_id=11278&page=45 

Santa Clara University Web Site. (2001, October 21). The Ethics of Human Cloning and Stem Cell Research. Retrieved November 11, 2010, from  http://www.scu.edu/ethics/publications/cloning.htm

Genetic Technology - Stem Cell esearch
Stem Cells

There has been an abundance of controversy over the past several years regarding the research of stem cells. Proponents of this particular branch of research claim that the usage of stem cells can create virtually unparalleled medical advantages for future generations. Opponents of the utilization of stem cells cite the fact that the research is unethical, primarily since it causes death in embryos to produce the advances which can significantly affect the future of health and wellness. However, careful consideration of bioethics, and in particular that of the consequentialist philosophy known as utilitarianism, indicates that stem cell research is both ethical and beneficial to the preservation of human kind.

Utilitarianism is the branch of philosophy pioneered by both John Stuart Mill and Jeremy Bentham that judges the morality of a particular action by its result. If an action produces more good than ill, it is…...

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References

Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R (2006). "Human embryonic stem cell lines derived from single blastomeres." Nature444 (7118): 481 -- 5.

Clout, Laura; and Agencies (2007-09-01). "Scientists report alternative stem cell source." The Daily Telegraph (London).

Do patients understand what it means to donate tissue to science? Not only that, but use of EG cells confuses stem cell research with the debate over abortion, bring up the risk of biasing emotions (McDonald 7).
So, while stem cell research is an exciting new field that holds much promise, ethical problems arise to delay research, discovery of benefits or dangers, and involve many who have no knowledge of the complexities of the field. Though controversies usually accompany new discoveries in science, this biotechnological process involves manipulating the basis of life itself in embryonic stem cells. But the field is rapidly changing. hat is true today may be outmoded tomorrow. A neutral substitute for stem cells may be discovered that will prove to be the answer to these ethical questions.

orks Cited

Ethics Committee of the American Society for Reproductive Medicine. "Financial incentives in recruitment of oocyte donors." Fertil Steril 2004;…...

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Works Cited

Ethics Committee of the American Society for Reproductive Medicine. "Financial incentives in recruitment of oocyte donors." Fertil Steril 2004; 82:Suppl 1:S240-S244.

Hwang, W.S., Roh, S.I., Lee, B.C., et al. -- Patient-specific embryonic stem cells derived from human SNCT blastocysts." Science 2005;308.

Magnus, David and Cho, Mildred K. "Issues in oocyte donation for stem cell research." Science Express Magazine, Stanford Center for Biomedical Ethics and Department of Pediatrics, Vol. 308. no. 5729, June 2005.  http://www.sciencemag.org/cgi/content/summary/308/5729/1747 .

McDonald, Chris. "Stem cells: a pluripotent challenge." BioScan Vol. 13, Iss. 4, (Toronto Biotechnology Initiative.) Fall 2001.

Essay Topic Examples
1. Ethical Implications of Embryonic Stem Cell Research:
    The essay can delve into the ethical controversy surrounding the use of human embryos in stem cell research. It should explore the various positions on the moral status of the embryo, the implications of creating and destroying embryos for research, and the debate over whether the potential medical benefits justify the ethical concerns.

2. The Debate on Federal Funding for Stem Cell Research:
    This topic involves examining the historical and current arguments for and against the allocation of government funds to stem cell research. The essay should discuss the impact of such funding on scientific advancement, the political controversy it creates, and how different administrations have approached the issue.

3. Advances in Induced luripotent Stem Cell (iSC) Technology and Its Impact on the Controversy:
    Focusing on iSCs, this essay would assess how this breakthrough in creating stem cells without the use of…...

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Primary Sources

National Institutes of Health (NIH). \"Stem Cell Information.\" U.S. Department of Health and Human Services, 2021.

NIH. \"Stem Cell Information.\" U.S. Department of Health and Human Services, 2021.  

Thomson, James A., et al. \"Embryonic Stem Cell Lines Derived from Human Blastocysts.\" Science, vol. 282, no. 5391, 1998, pp. 1145–1147.

Thomson, James A., et al. \"Embryonic Stem Cell Lines Derived from Human Blastocysts.\" Science, vol. 282, no. 5391, 1998, pp. 1145-1147.

Lo, Bernard, and Lindsay Parham. \"Ethical Issues in Stem Cell Research.\" Endocrine Reviews, vol. 30, no. 3, 2009, pp. 204–213.

Lo, Bernard, and Lindsay Parham. \"Ethical Issues in Stem Cell Research.\" Endocrine Reviews, vol. 30, no. 3, 2009, pp. 204-213.

President\'s Council on Bioethics (U.S.). \"Monitoring Stem Cell Research.\" President\'s Council on Bioethics, January 2004. https://stemcells.nih.gov/ .

Essay Topic Examples
1. The Ethical Dimensions of Embryonic Stem Cell Research:
     This essay would delve into the controversial aspects of embryonic stem cell research, focusing on the debate surrounding the moral status of the embryo. It would explore the ethical implications of using embryonic tissue, the potential consequences for societal values, and the various positions held by religious groups, ethicists, and scientists.

2. A Comparative Analysis of International Stem Cell Research olicies:
     An examination of how different countries approach the regulation of stem cell research could be the focus of this essay. It would analyze the spectrum of policies from permissive to restrictive, the influence of cultural and moral perspectives on legislation, and the impact of such variation on international scientific collaboration and progress.

3. Stem Cell Research: A athway to Medical Breakthroughs vs. Ethical Quandaries:
     Here, the essay could assess the potential medical benefits of stem cell research,…...

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Primary Sources

National Institutes of Health. \"Stem Cell Information.\" U.S. Department of Health and Human Services, NIH,  

International Society for Stem Cell Research. \"Guidelines for Stem Cell Research and Clinical Translation.\" ISSCR, 2021,  https://www.isscr.org/ 

U.S. Food and Drug Administration. \"FDA Regulation of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/P\'s) Product List.\" FDA,  https://www.fda.gov/ 

Lo, Bernard, and Lindsay Parham. \"Ethical Issues in Stem Cell Research.\" Endocrine Reviews, vol. 30, no. 3, 2009, pp. 204-213,  https://doi.org/10.1210/er.2008-0031 

The President\'s Council on Bioethics. \"Monitoring Stem Cell Research.\" 2004, The President\'s Council on Bioethics, https://bioethicsarchive.georgetown.edu/pcbe/

https://stemcells.nih.gov/ 

To date, adoptive T-cell therapy have used peripheral blood, tumors, malignant effusions, and drained lymph nodes as sites for injecting the T-cells for adoptive transfer. Those are routinely used are allogenic bone marrow transplantation and peripheral blood stem cell infusion. It is possible that the bone marrow might be a good place too. It is also arguable which precise T-cells are the best to transfer, since T- cells are differentiated into many subsets.

Furthermore, in order to produce enough effectors T-cells, specific T-cells from peripheral blood or tumor specimens are isolated and generated in vitro, and these are then clonally expanded using various approaches. The T-cells are then reinfused into the patient with the expectation that they will then target antigens. There is much evidence that this approach works, although it also seems that this can be engineered in vivo under certain situations.

For most effective T-cell therapy, it has been shown…...

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Sources

Greenberg, P.D. 1991, 'Adoptive T cell therapy of tumors. Ad. Immunol. 49, pp. 281-355.

Jamieson, B.D., & Ahmed, R. 1989,'T cell memory. J. Exp. Med. 169, pp. 1993-2005

June, C.H. 2007, 'Principles of adoptive T cell cancer therapy', J. Clin. Invest., 117, pp.11204-1212.

MedecineNet.com. Definition of T cell. Online. Available at:  http://www.medterms.com/script/main/art.asp?articlekey=11300

Stem Cell Research / Parkinson's
Since Barack Obama has become president, the field of stem cell research has been given new life. One of Obama's campaign pledges

was to allow deeper research -- including the use of federal research funds -- into the use of pluripotent stem cells in order to find solutions for some of the terrible diseases Americans suffer from. Among those medical problems is Parkinson Disease (PD). This paper reviews and delves into the literature in terms of the potential of stem cell interventions into Parkinson Disease (also called "Parkinson's Disease").

ho is the leading authority on stem cell research?

There is no one "leading authority" reflected in the literature; however there are renowned scientists that are considered pathfinders in this field. Dr. Diane S. Krause, Associate Professor of Laboratory Medicine and Associate Director of Stem Processing at Yale University is "…one of the discoverers of previously unknown innate sources of…...

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Works Cited

Gallup Poll. (2011). Stem Cell Research. Retrieved March 7, 2012, from  http://www.gallup.com/poll/21676/stem-cell-research.aspx .

Gogel, S. Gubernator, M., and Minger, SL. (2011). Progress and prospects: stem cells and Neurological diseases. Gene Therapy, 18(1), 1-6.

Krause, D.S. (2002). Plasticity of marrow-driven stem cells. Gene Therapy, 9(11), 754-8.

Lo, Bernard, and Parham, Lindsay. (2010). Resolving Ethical Issues in Stem Cell Clinical

Analysis of the Issues: The ethical concern for the rights and welfare of viable infants is certainly a legitimate concern, but the central ethical analysis that pertains to stem cell research revolves around the issue of defining human life appropriately. Objective criteria like anatomical development, cognitive awareness, and above all, sentience of any degree and in any form are all legitimate bases for the definition of life and for identifying the period of gestation corresponding to the earliest conceivable safeguards necessary to prevent suffering.

On the other hand, purely subjective doctrinal claims without objective criteria of any kind are wholly inappropriate bases for defining scientific concepts like when life begins. The fact that human development varies among individuals and that it may be impossible to know exactly where sentience and other elements of "humanness" first begin in the fetus does not mean that it is impossible to identify periods of fetal…...

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References

Dershowitz, a.(2002) Shouting Fire: Civil Liberties in a Turbulent Age.

Boston: Little Brown, 2002

Healy, B. On Health: The Other Stem Cells; U.S. News & World Report (Jun. 14/04), p. 77.

Hellemans, a., Bunch, B. (1998) the Timetables of Science. New York: Simon & Schuster.

3.3 Data Collection

Is maternal UE3A active following iPS treatment: Data will be gathered on the iPS-treated mice via positron emission tomography, and in vivo brain slice preparation, and Western lot Analysis. H1 will essentially be ascertained following these tests.

Does iPS treatment rescue the motor and cognitive deficits associated with Angelman Syndrome: Data will be gathered from testing the treated mice in scientifically recognized tests of cognitive ability in a mouse model. This project proposes using the water maze test, the electric shock test, and the submerged platform test. H2 will effectively be answered using the data gleaned from these tests.

4. Conclusion

4.1. Potential Therapeutic and Other Considerations

The potential of using iPS treatment to rescue/alleviate the severe motor and cognitive deficits witnessed in Angelman Syndrome is theoretically viable. Reliable mouse models of AS exist with which to run the tests. The technology needed to tease iPS stem cells into fully functioning brain…...

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Bibliography

Abuhatzira, L., Shemer, R., & Razin, A. (2009). MeCP2 involvement in the regulation of neuronal alpha-tubulin production. Human Molecular Genetics, 1415-1423.

Condic, M.L., & Rao, M. (2008). Regulatory Issues for Personalized Pluripotent Cells. Stem Cells, 2753-2758.

Dindot, S., Antalffy, B., Meenakshi, B., & Beaudet, A. (2008). The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Human Molecular Genetics, 111-118.

Dobkin, B. (2007). Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke. Stroke, 832-839.

For some the issue then arises when the pluripotent cells are removed from the blastocyst, as this very act negates the ability for the cell group to develop into a human being. "Note that the process of changing from totipotent to pluripotent to multipotent cells is not reversible -- that is, pluripotent stem cells do not produce totipotent stem cells, and multipotent stem cells do not produce pluripotent stem cells."

Borror, O'Rourke and Skirboll 54) Additionally, the proponents of stem cell work cite the pluripotent as incapable of producing a human being therefore not a destruction of life, hence leading to the Bush decision to ban the creation of new lines of stem cells, as it would require the destruction of further human totipotent cells.

Multipotent. The pluripotent stem cells undergo further specialization into multipotent stem cells, which are committed to giving rise to cells that have a particular function. Examples of…...

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Works Cited

 

Stem Cell Ethics
Debating the Ethics of Stem Cells

The term 'stem cells' can mean different things to different people. For some, it conjures images of medical miracles providing solutions for heart disease, diabetes, and dementia. For others, it terrifies with a future filled with cloned humans. Still others cringe at the thought of mass producing cultured human embryos for the sole purpose of providing organs and tissues for a paying public. As with most complex issues, news media coverage tends to exaggerate easily understood concepts at the expense of the overall truth and the public accordingly remains ignorant of the subtleties surrounding this debate. This seems to add fuel the emergence of polarized camps and a shrinking of a common middle ground. To better define this middle ground, this essay will discuss both sides of this debate and argue instead that the vast majority of people would likely support an intermediate…...

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Works Cited

Antiniou, Michael. "The Case Against & #8230;" Nature Medicine 7.4 (2001): 397-399. Web. The author argues that the use of embryonic stem cells for research and medicine poses significant ethical and moral issues that cannot be overcome. Of particular concern is the potential for reproductive cloning, a door that the author believes was opened when the UK government approved the use of embryonic stems cells for research and medicine.

Blow, Nathan. "In Search of Common Ground." Nature 451.7180 (2008): 855-858. Web. The author presents several issues facing researchers who work with stem cells and discusses why they are important to advancing this field of research. Of primary concern is developing standard protocols for producing stem cells and creating the necessary protocols and reagents that will allow the therapeutic use of stem cells in humans.

Leeb, C., Jurga, M., McGuckin, C., Forraz, N., Thallinger, C., Moriggl, R. et al. "New Perspectives in Stem Cell Research: Beyond Embryonic Stem Cells." Cell Proliferation 44.1 (2011): 9-14. Web. The focus of this article is the promises and limitations of embryonic, adult, and induced pluripotent stem cells, from the perspective of scientists working in this field. The ethical decisions concerning the use of embryonic stem cells are only mentioned in passing.

Power, Carl and Rasko, E.J. "Promises and Challenges of Stem Cell Research for Regenerative Medicine." Annals of Internal Medicine 155.10 (2011): 706-713. Web. The authors discuss in detail the three main types of stem cell technologies: embryonic, adult, and induced pluripotent. Ethical issues are mentioned occasionally, but not discussed.

Persuasive Essay Topic Ideas

Education

The Importance of Early Childhood Education
Should College Education Be Free for All?
Technology's Role in Enhancing Education
The Value of Experiential Learning over Traditional Classrooms
The Impact of Standardized Testing on Student Success

Social Issues

The Necessity of Universal Healthcare
The Right to Bear Arms: A Constitutional Imperative
The Impact of Social Media on Mental Health
The Importance of Gun Control Legislation
The Benefits of a Universal Basic Income

Environmentalism

Climate Change: A Call to Action
The Necessity of Renewable Energy Sources
The Role of Individuals in Environmental Protection
The Impact of Deforestation on Biodiversity
The Benefits....

Here are some science essay topics that may help you learn more about various fields of science:

1. The impact of climate change on the environment
2. The importance of genetic engineering in modern agriculture
3. The ethical implications of artificial intelligence and robotics
4. The role of vaccines in preventing the spread of infectious diseases
5. The future of renewable energy sources like solar and wind power
6. The benefits and risks of using CRISPR technology in gene editing
7. The impact of plastic pollution on marine life
8. The science behind the COVID-19 pandemic and the development of vaccines
9. The role of stem cell research in....

Limbal epithelial stem cells (LESCs) have been a subject of extensive research in recent years due to their crucial role in maintaining the integrity and function of the cornea. Several literature reviews have provided key findings that have advanced our understanding of the biology and therapeutic potential of these stem cells.

One key finding from literature reviews is the identification of specific markers that can be used to isolate and characterize LESCs. These markers include transcription factors such as p63 and ABCG2, as well as cell surface markers like integrin ?9 and nerve growth factor receptor. By utilizing these markers,....

The research on limbal epithelial stem cells (LESCs) has seen significant advancements with the integration of single-cell RNA sequencing (scRNA-seq) technologies. This technique has allowed for a deeper understanding of the cellular heterogeneity within the limbal epithelium, which is crucial for the regeneration of the corneal epithelium. One of the key findings from recent literature is the identification of distinct subpopulations of LESCs, which differ in their gene expression profiles, suggesting varied functional roles in corneal homeostasis and regeneration.

Studies utilizing scRNA-seq have revealed that LESCs are not a homogeneous population but rather consist of multiple subpopulations with unique transcriptional signatures.....