Tumor Suppression Protein 53 and Effects on Cellular Function and Aging
Tumor Suppression Protein 53 (P53) was originally linked to tumor proliferation and thought to be an oncogene. Research led to an understanding that P53 was in actuality a tumor suppression protein and suppression of the P52 gene is the most widely genetic defect found in tumors (Levine 1991). Further study of p53 and the family of tumor suppression genes led to the understanding that these proteins are responsible for slowing the growth of cells. Through the study of tumor growth and the search for a mechanism that led to accelerated cellular growth in tumors it was found that tumor cells selectively suppress genes that transcribe proteins that lead to apoptosis. The fine line between cells that can divide and live forever and cells that die in a normal life cycle can be heavily impacted by tumor suppression proteins including P53 (Pierra-Smith 1983). Apoptosis, or programmed cell death, is a major factor in aging and the activation of p53 is directly linked both to stabilization and to protection from unchecked growth.
Introduction-Cellular Function and p53
Cell death is a normal process in the life cycle of cells. Cells can either be killed by an exterior factor, termed necrosis or an active process of self-destruction termed apoptosis. Apoptosis is a normal process and requires energy in the cell life cycle and a specific pathway and proceeds with specific signaling pathways that halt functions of...
Cellular Function and Aging Tumor Suppression Protein 53 and Effects on Cellular Function and Aging The concept of aging has many intrinsic and extrinsic factors that act as markers on an individual organism. Ignoring mortality associated with external environmental factors, very few organisms can be said to have cellular immortality with no decrease in cellular function or repeat division in normal diploid cells. Cellular senescence is a normal process that halts
Tumor Suppressor p53 The p53 tumor suppressor, also known as the TP 53 or tumor protein can be referred to as a gene that codes for a protein that is responsible for the regulation of the cycle of the cell and therefore acting as tumor suppression. It is significant for cells in multicellular organisms to suppress cancer, p53 has been referred to as ‘the guardian of the genome’ as extracted from
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123). In this study, Martinez-Contreras and her associates report the results of recent research that has provided additional evidence concerning the function of these proteins in precursor-messenger RNA (pre-mRNA) splicing (2007). The splicing repression can function in two discrete ways in heterogeneous nuclear RNP proteins; the first way is by antagonizing the recognition of splice sites directly and the second way is through interference with the binding of proteins that
Immune System and Stress How quickly a deceased human (or animal) body breaks down is testament to how well the immune system works. While a body is alive, the immune system protects the body at every living moment from bacteria and other foreign invaders. The immune system is a complex system of cells -- which have varying functions -- and generated at discreet regions of the body, a circulatory system --
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