Tricyclic antidepressant use to mitigate chronic low back pain has been investigated by researchers as a form of treatment for decades. Some articles go as far back as 1986. The types of antidepressants tested for efficacy in treatment of chronic low back pain have been either tricyclic or tetracyclic. Systematic reviews from twelve years ago noted antidepressants treat pain via inhibition of norepinephrine reuptake (Staiger, Gaster, Sullivan, & A Deyo, 2003. Antidepressants that failed to inhibit norepinephrine reuptake did not provide any benefit in pain relief. New modalities of treatment with antidepressants use not just one, but a combination of tricyclic antidepressants like Pregabalin and Amitriptyline.
Pregabalin, otherwise known as Lyrica, is a nerve pain medication. Uses for the drug include treatment of seizures, fibromyalgia and nerve and muscle pain. Amitripyline (Elavil), is a standard treatment for depression and works as a never pain medication. Some medical practitioners have also prescribed the drug for insomnia (Atkinson & Sullivan, 2013).
These drugs have been reviewed as treatment separately or together. Drugs that treat nerve pain are important because chronic lower back pain consists of mainly neuropathic or nerve pain like sciatica or lumbar radiculopathy (Jacobson et al., 2015). If drugs like Pregabalin and Amitriptyline can be used to diminish nerve pain, this would be the most likely treatment option for chronic lower back pain. The strategies focus on seeing if Pregabalin or Amitriptyline work as a main treatment option for chronic lower back pain or if Pregabalin and Amitriptyline work best together.
The search strategy uses Pregabalin and Amitriptyline as main keywords, allowing search results to produce current (less than five years old) articles that show efficacy of either or, and dual treatment options. Along with the use of these two, main keywords, antidepressants and chronic low back pain were also used to highlight previous and current use of antidepressants for the treatment of chronic lower back pain.
The first article covers antidepressant use in those that suffer from lower back pain among other treatment options. Interestingly the treatment option of antidepressants was not used primarily for pain management....
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