Transplant Medicine
The Major Histocompatibility Complex (MHC) contains over 128 functional genes. This is the densest part of the human genome and is responsible for most autoimmune diseases. This region also determines vaccine responsiveness, adverse drug reactions, disease progression and transplant rejection. The MHC genes are multigenic with a high degree of allelic polymorphism. There are over 7,500 different alleles and over 5,458 expressed MHC antigens currently known. (DeFranco, Locksley & Robertson, 2007). Genomic evolution and HLA screening have been extremely profitable to Transplant Medicine.
A brief analysis of MHC variability reveals two classes of antigens belonging to this complex; class I (A, B, and C) and II (DR, DQ, and DP). Both classes of molecules are expressed in a co-dominant fashion. These molecules are designed to recognize antigens that are foreign to the body and present them to the T cells. (Janeway, Travers & Walport, 2001)
The co-dominant mode of inheritance of MHC genes assures that each individual will have a distinct antigen on their cell surface. This forms the basis of graft rejection. Once a foreign antigen enters the human body, activation, proliferation and differentiation of lymphocytes into effector cells continues until the foreign antigen is eliminated, after which the immune system returns to its quiescent state and an immunologic memory is generated. (Janeway, Travers & Walport, 2001)
Tissue typing to match HLA antigens is an important step before transplantation. In general, the larger the number of matched MHC alleles between the donor and the recipient, greater are the chances of graft survival. However, routine HLA typing focuses only on HLA-A,...
In theory, such evaluations could be useful, but as is, they are fairly useless. Plus, the validity and necessity of evaluations are up for debate themselves, besides the actual results from the evaluations being up for debate. Thus, the bioethical dilemma in those who abuse their bodies before and after receiving organ transplants lies not necessarily just with the recipients, but also with society, and with the medical field with
Ethical Considerations Behind Organ Transplants The idea of organ transplants has suffered several criticisms over the years from the civil society, to the various religious groups and even philosophers. It is challenging to have one perspective on the idea of transplants and apply it universally since not everyone will share the religious view, or the philosophical view. In the context of this memorandum, the utilitarian philosophy will be the baseline for
In the U.S. For instance, Abuona (2003) indicated that the very first criterion is the donor's geographic location as compared to that of the recipient followed by the histocompatibility matching and blood group compatibility. The third criterion is a point system that each of the waiting-list patients accumulate in regard to the following variables; waiting time, medical urgency, as well as the age of the patient. This allocation technique
Organ Transplantation Denying Mrs. Burgone the organ transplant could be ethically justified under certain conditions and circumstances. However, denying her organ transplantation surgery under these circumstances is not one of those instances and cannot be ethically justified. The decision is arbitrary and serves no purpose for any stakeholders in the outcome of the issue. Moreover, the ethical justification purported to be at the heart of the decision is logically flawed and
Organ Donation Why Organ Donating is a Social Responsibility Life is a sentence. It begins with a capital letter, has something in between, and then a punctuation mark at the end. Organ donation allows part of our physical body to be of use to someone else for short time after we have passed. It is a beautiful gift to be able to make someone else's life a little longer. This gives them
2009). The susceptibility is highest is the first month of the transplantation and decreases afterwards. it, however, remains high even after 12 following. Susceptibility is highest among kidney recipients who are more likely to develop the infection 12 months after the transplantation. They have a lower mortality rate than liver transplant recipients. The study also reflected a trend in increasing antimicrobial resistance among these susceptible recipients. The E-coli strain
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