Rheumatoid arthritis is a widespread autoimmune disease that is linked to progressive disability, socioeconomic costs, systemic complications, and even early death. In addition to having an unknown cause, the disease also has a guarded prognosis. In the past few years, there have been several attempts to understand the pathogenesis of the disease, which have resulted in the creation of new therapeutics with enhanced outcomes (McInnes & Schett, 2011, p.2205). As a result of this progress, the current treatment strategy for the disease involves initiating aggressive therapy immediately after diagnosis and increasing the therapy. This process is carried out through an evaluation of the disease activity in order to achieve medical remission. While various unmet needs remain, rheumatoid arthritis is characterized by synovial inflammation, systemic attributes, autoantibody production, and cartilage and bone destruction.
Question 2:
Despite being common in the environment, Acinetobacter bacteria are rarely a medical threat to healthy and uninjured people. Acinetobacter infection can take place through person-to-person contact, exposure to contaminated surfaces, or contact with wounds contaminated with debris and dirt. Notably, very ill individuals, those with tramautic wounds, and those undergoing treatment in intensive care units are more vulnerable to infection with difficult-to-treat Acinetobacter bacteria. The symptoms of these infections differ based on the specific body part affected by bacteria. The symptoms for an Acinetobacter infection caused by pneumonia include chills, shortness of breath, fever, and cough.
Question 3:
A transfusion reaction is a condition that occurs when an individual is receiving blood or immediately after blood transfusion. While a blood transfusion is an important and effective means to help restore strength and health for an individual who has experienced serious blood loss, it's vital that the blood is precisely matched to the person's blood type. Failure to ensure...
p { margin-top: 10px; margin-bottom: 10px; } Rheumatoid Arthritis (RA) Pathophysiology Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder that primarily affects the joints but can also have widespread systemic manifestations. The pathophysiology of RA involves an intricate interplay between genetic factors, environmental triggers, immune system dysregulation, and inflammatory pathways that lead to joint damage and systemic complications. Genetic Susceptibility Genetic susceptibility plays a
Autoimmunity The immune system of the body must differentiate itself from harmful to repel invaders and to protect the integrity of the host without inducing autoimmunity. Any deficit in this function can cause the body to be vulnerable to infections, malignancies or over-reactivity to innocuous antigens, resulting immunopathology and autoimmunity. Autoimmunity is defined by pathological immune-based reactions which are usually persistent and have long duration, which involve self-antigens (autoantigens). Its clinical expression
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