Verified Document

Renin-Angiotensin System And Control Of Blood Pressure Essay

Endocrine control of BP Hormonal Control of Osmotic pressure: Stimulation

Arterial blood pressure (BP) is under tight control by the mammalian nervous system, cardiovascular system, kidneys, and endocrine system (Vivas et al., 2014). The VII, IX, and X cranial nerves conduct peripheral taste, osmo-sodium, volume, and baroreceptor information to the solitary tract, while the distinct bundles of neurons in the lamina terminalis respond to changes in plasma and cerebral spinal fluid sodium levels, osmolality, and angiotensin II levels. The information thus received is transmitted to the median preoptic, supraoptic, paraventricular, lateral parabrachial, and dorsal raphe nucleus for integration. The neurotransmitter systems involved include angiotensin, vasopressin, oxytocin, and serotonin.

The overall response to reductions in BP and electrolyte content of bodily fluids is to trigger the sympathetic nervous system, endocrine system, and appropriate behavior to correct the deficiency (Vivas et al., 2014). The most important arm of BP control is the renin-angiotensin-aldosterone system, which mediates both short-term and long-term BP regulation (Chopra, Baby, and Jacob, 2011). Plasma angiotensinogen, a 453-aa protein, is produced by the liver and enzymatically cleaved by renin to produce the 10-aa peptide, angiotensin I, which induces mild vasoconstriction. Renin is produced by the juxtaglomerular cells in response...

Angiotensin I can be further cleaved by angiotensin converting enzyme-1 (ACE1), primarily in the lungs, to produce the 8-aa angiotensin II, which induces arterial constriction and a measurable increase in BP. ACE1 also inactivates bradykinin, further promoting an increase in BP (Duka et al., 2006).
Angiotensin II mediates its effects through two receptors, AT1 and AT2, each producing opposing activities (Chopra, Baby, and Jacob, 2011). Activation of AT1 induces vasoconstriction, anti-diuresis, anti-natriuresis, cell growth, and proliferation, while activation of AT2 results in vasodilation, dieresis, natruiresis, and anti-proliferation. Although both receptors can be found in tissues throughout the body, the control of BP and the content of body fluids are mediated primarily by receptors expressed in the kidneys (Farrao, Lara, & Lowe, 2014). Angiotensin II will also stimulate anti-diuretic hormone release from the pituitary, thereby promoting increased water reabsorption in the renal collecting ducts, induce aldosterone production from the adrenal cortex, induce sodium reabsorption in the kidneys, and promote potassium and hydrogen excretion through the kidneys. The importance of the kidneys in controlling blood pressure is highlighted by…

Sources used in this document:
References

Chopra, S., Baby, C., & Jacob, J.J. (2011). Neuro-endocrine regulation of blood pressure. Indian Journal of Endocrinology and Metabolism, Suppl. 4, S281-8.

Duka, A., Duka, I., Gao, G., Shenouda, S., Gavras, I., & Gavras, H. (2006). Role of bradykinin B1 and B2 receptors in normal blood pressure regulation. American Journal of Physiology, Endocrinology and Metabolism, 291(2), E268-74.

Farrao, F.M., Lara, L.S., & Lowe, J. (2014). Renin-angiotensin system in the kidney: What is new? World Journal of Nephrology, 3(3), 64-76.

Vivas, L., Godino, A., Dalmasso, C., Caeiro, X.E., Macchione, AF., & Cambiasso, M.J. (2014). Chapter 9: Neurochemical circuits subserving fluid balance and baroreflex: A role for serotonin, oxytonin, and gonadal steroids. In L.A. De Luca Jr., J.V. Menani, & A.K. Johnson (Eds.), Neurobiology of body fluid homeostasis: Transduction and integration (pp. 141-166). Boca Raton, FL: CRC Press.
Cite this Document:
Copy Bibliography Citation

Related Documents

Main Systems of Human Body
Words: 3828 Length: 12 Document Type: Essay

The circulatory or cardiovascular system is responsible for moving nutrients, wastes and gases between body cells, transporting blood across the whole body and battling disease (Circulatory System). Its principal elements are the heart, numerous blood vessels, and blood. The heart forms the circulatory system's core. This 2-sided, 4-chambered pump which distributes blood to various arteries comprises of the right and left ventricles, and right and left atria. The ventricles, situated within

Cardiology Nursing This Is a 12 Lead
Words: 3533 Length: 13 Document Type: Case Study

Cardiology Nursing This is a 12 lead ECG taken for Mr. Long at the Emergency Department. He presented with a two hour history of chest pain radiating to his left arm. The ECG is suggestive of an antero-septal Myocardial infarction. Further scrutiny of the ECG displays a normal sinus rhythm, with a rate of 75 bpm that is regularly regular. There is no axis deviation with a PR interval of 200

Does Hypertension Have a Genetic Basis
Words: 1305 Length: 5 Document Type: Research Paper

Introduction Hypertension is the chronic elevation of blood pressure that can lead to organ failure and even mortality. Cardiac output creates blood pressure but in patients with hypertension, cardiac output is increased. The autonomic nervous system helps to regulate blood pressure but in patients with hypertension, no repinephrine is existent and stress is felt especially acutely. Phenotype and Genotype It is unknown what genes cause hypertension. Moreover, as Korner (2010) points out, “their

Analyzing Hypertensive Patient Case Study
Words: 845 Length: 2 Document Type: Case Study

Hypertensive Patient Case Study Specific physical examinations in any hypertensive patient Accuracy in the measurement of blood pressure is the basic aspect of diagnosis. Therefore, we take it over several weeks. On each visit, normally at least three blood pressure readings are taken with the difference of 2 minutes using mercury manometer. Palpation of all peripheral pulses should necessarily be carried out. Absent, weak, or delayed femoral pulses are the sign of coarctation

Kidney Function and Orthostatic Hypotension
Words: 1327 Length: 4 Document Type: Essay

Orthostatic Hypotension Blood pressure is the strength of blood pushing against arteries’ walls as the heart beats. Adults have a 120/80 mmHg e normal blood pressure. The numerator represents the systolic pressure which is the measure of blood pressure during active heart beats while the denominator represents the diastolic pressure, which is the blood pressure during passive heart beats (Low & Tomalia, 2015). Consistent rise of blood pressure to over 140/90 mmHg

Osmoregulation Endocrines Osmoregulation Is the Process, by
Words: 2423 Length: 8 Document Type: Essay

Osmoregulation Endocrines Osmoregulation Osmoregulation is the process, by which the body adjusts to a change in an environment of different water volume and amount of solutes in a cells and body fluid of organisms including vertebrates. Vertebrates are animals, which have a backbone, and can be warm either blooded or cold blooded. The body of such organisms adjusts in order to maintain the body balance both inside and outside their bodies in

Sign Up for Unlimited Study Help

Our semester plans gives you unlimited, unrestricted access to our entire library of resources —writing tools, guides, example essays, tutorials, class notes, and more.

Get Started Now