Bellinger, a.M., Mongillo, M., & Marks, a.R. (2008). Stressed out: the skeletal muscle
Ryanodine receptor as a target of stress. Journal of Clinical Investigations. 118(2):
In this report prior the researchers addressed overall present understanding of muscle fatigue. For decades, the mechanisms underlying muscle fatigue and weakness were the emphasis of numerous studies. The dominant theory was that lactic acidosis caused muscle fatigue. However, dysregulation of sarcoplasmic reticulum (SR) Ca2+ release has been associated with impaired muscle function induced by a variety of stressors, from dystrophy to heart failure to muscle fatigue. Here, the authors addressed the topic of the altered regulation of SR Ca2+ release during chronic stress and focused on the role the release channel known as the type 1 ryanodine receptor plays.
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