Kao, W.Y., Su, C.W., Huang, Y.S., Chou, Y.C., Chen, Y.C., Chung, W.H., ... & Wu, J.C.
Risk of oral antifungal agent-induced liver injury in Taiwanese. British Journal of Clinical Pharmacology, 77(1), 180-189.
The researchers claim that drug-induced liver injury (DILI) is the most common cause of acute liver failure in the United States and a major issue in other countries. DILI is a serious health problem that has major ramifications on physicians, patients, pharmaceutical industry and government regulators. The use of oral antifungal agents has resulted in some well publicized cases of serious liver injuries leading to death even though the incident rates of DILI are low. Almost half of patients in Taiwan infected with oychomycosis refuse to be treated with oral antifungal agents because of concerns regarding potential liver injury. There has not been a study of antifungal-agent produced DILI for people in Taiwan and the current study attempted to examine the incidence of liver injures associated with oral antifungal use in Taiwan and to identify the risk factors for untoward liver issues in Taiwanese participants who use oral antifungal agents.
The Longitudinal Health Insurance Database (years 2002-2008) was utilized from the National Health Insurance program in Taiwan covering greater than 98% of the population in that country. A total of 90,847 patients who used antifungal agents were identified in the study of which 69, 665 were compared to a randomly extracted control group...
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