Verified Document

Hydroxyurea Segal, J.B., Et Al., 2008 , Hydroxyurea Essay

Related Topics:

¶ … Hydroxyurea Segal, J.B., et al., (2008), Hydroxyurea for the Treatment of Sickle Cell Disease,

Baltimore, MD: AHRQ

Variables/Key Concepts

To determine efficacy, effectiveness, harms, and barriers of the use of hydroxyurea treatment of sickle cell disease for determining solutions and further research need.

Sampling

Research studies based on variables.

Conducted by experts in sickle cell disease management, clinical trial methodology, systematic review, epidemiological studies, and ethics and adherence research.

Instruments/Data Collection

Instruments were quality assessment, data extraction, and evidence grading. Literature inclusion tailored toward research questions. Studies on children and adults evaluated separately. Included randomized trials, non-randomized trials, cohort studies with control groups, and pre/post studies. Evaluations of data was based on variable-based research questions.

Results

Hydroxyurea lowered the rate of hospitizations among children with sickle cell disease and raised HbF cell percentages.

Strengths/Limitations

Limited evidence for toxicity, barriers, and guide dosing. Insufficient evidence for efficacy and safety.

Critique

Even with the use of experts, there was no appropriate design method mentioned. Identifies research needs for toxicity, guide dosing, efficacy, and safety.

Strouse, J.J., et al., (2008), Hydroxyurea for Sickle Cell Disease: A Systematic Review for Efficacy and Toxicity in Children, Pediatrics, 122:6. Doi:10.1542/peds.2008-0441,

Retrieved from http://www.pediactricsdigest.mobi/content/122/6/1332.full

Variables/Key Concepts

A synthesized literature review on the efficacy, effectiveness, and toxicity of hydroxyurea in children.

Sampling

Selected randomized trials, observational studies, and case reports that evaluated the efficacy, and toxicity of hydroxyurea in children with sickle cell disease.

Design/Method

Two reviewers abstracted data sequentially in study design, patient characteristics, and outcomes. Assessed study quality independently.

Instruments/Data Collection

Instruments were databases,...

Used studies of randomized controlled trials, cohort studies with control groups, and pre/post studies.
Results

Strong evidence of increasing HbF and decreasing hospitalization. Moderate evidence of decreasing pain crisis and support of increased risk of reversible cytopenias, and rash. Weak evidence for decreasing neurologic events. Distance to referral center and need of frequent monitoring may be barriers to use.

Strengths/Limitations

Limited predictors to response.

Critique

No defined methodology. Good to evaluate for barriers to use of hydroxyurea as well as suggestions for further research on neurologic events and more evidence on reducing pain measures.

Kavanagh, P.L., et al., (2011), Management of Children with Sickle Cell Disease: A

Comprehensive Review of Literature, Pediatrics, 128:6. Doi:10.1541/peds.2010-3686,

pp e1552-e1574, retrieved from http://pediatrics.aappublications.org/content/1128/6/e1552.full.pdf+hml

Variables/Key Concepts

Review the quality of literature for preventative interventions and treatment of complications to facilitate the use of evidence-based medicine and need of further research.

Sampling

Randomized cohort cases, controlled studies, multiple time series studies, and uncontrolled studies.

Design/Method

Identified data based on relevant topics dated from January 1995 to April 2010. Data was independently reviewed by two experts.

Instruments/Data Collection

Instruments were common form, U.S. Preventative Service Task Force ratings, RCTs, and meta-analysis categorized. Isolated studies based on relevancy of 28 topics concerning National Institute of Health guidelines for the care of children with sickle cell disease under three categories.

Results

Lack of quality research for pediatric sickle cell disease related topics, many areas lack RCTs, and more research is needed for health and well-being of children with sickle cell disease.

Strengths/Limitations

Possible missed studies due to refined strategies, more than one third of studies included adults and children,…

Cite this Document:
Copy Bibliography Citation

Related Documents

Anemia Is Defined As a Condition in
Words: 1646 Length: 5 Document Type: Research Paper

Anemia is defined as a condition in which the body does not have enough healthy red blood cells in order for oxygen to be carried to tissues (Mayo Clinic, 2010). Red blood cells are shaped like discs and resemble doughnuts without holes in the middle (National Heart Lung and Blood Institute, 2010). Red blood cells are manufactured in bone marrow, and their function is to carry oxygen throughout the body

Anemia Iron Deficiency Anemia Is
Words: 1260 Length: 4 Document Type: Research Paper

D.). According to Brody (2008), "Babies are born with about 500 milligrams (mg) of iron in their bodies. By the time they reach adulthood they need to have about 5,000 mg." Tympa-Psirropoulou et al. (2008) outline the three stages during which iron deficiency anemia develops in infants. First, iron stores in the body become gradually depleted. "Iron is an essential part of hemoglobin, the oxygen-carrying protein in blood," (Brody 2008). This

Anemia Huma, Nuzhat, Salim-Ur-Rehman, Faqir
Words: 942 Length: 3 Document Type: Thesis

Direct supplementation is often the best method to immediately counteract the effects of anemia. But supplementation alone on a long-term basis is seldom recommended as the sole course of treatment -- dietary rectification is usually required for sustained improvement. Food -- based strategies can include the introduction of iron-rich foods. But in many nations these types of foods may be poorly available, especially iron-rich meat. Iron fortification of foods is

Anemia Treatment
Words: 641 Length: 2 Document Type: Case Study

signs of anemia that is caused by blood loss. Anemia caused by blood loss can take place over long periods of time, and in Ms. A's situation, that could be what is taking place. According to her medical history, she has been suffering from "menorrhagia" and "dysmenorrhea," both of which are signs of anemia in women, especially during child-birthing years. Other signs of anemia in the patient include the

American Society and Anemia
Words: 683 Length: 2 Document Type: Essay

Anemia Case Study The circumstances and preliminary workup in Ms. A's case indicates that she is suffering from a certain type of anemia. Even though she is an apparently healthy woman, Ms. A's conditions worsen during her menstruation period. Generally, anemia is a condition that is brought by the impaired or increased generation of erythrocytes and is also known as iron poor blood. Athletes who engage in endurance training such as

Pernicious Anemia I Uploaded Instructions. The Essay
Words: 1006 Length: 3 Document Type: Essay

Pernicious Anemia I uploaded instructions. The essay written ASA format, scholarly references pages. Pernicious anemia is a medical condition where the body is unable to manufacture the required red blood cells due to the lack of enough vitamin B12. According to Ban-Hock and Alderuccio (2004) vitamin B12 is used in the body for making healthy red blood cells and to ensure the nervous system is functioning properly. Persons suffering from pernicious anemia

Sign Up for Unlimited Study Help

Our semester plans gives you unlimited, unrestricted access to our entire library of resources —writing tools, guides, example essays, tutorials, class notes, and more.

Get Started Now