¶ … Hydroxyurea
Segal, J.B., et al., (2008), Hydroxyurea for the Treatment of Sickle Cell Disease,
Baltimore, MD: AHRQ
Variables/Key Concepts
To determine efficacy, effectiveness, harms, and barriers of the use of hydroxyurea treatment of sickle cell disease for determining solutions and further research need.
Sampling
Research studies based on variables.
Conducted by experts in sickle cell disease management, clinical trial methodology, systematic review, epidemiological studies, and ethics and adherence research.
Instruments/Data Collection
Instruments were quality assessment, data extraction, and evidence grading. Literature inclusion tailored toward research questions. Studies on children and adults evaluated separately. Included randomized trials, non-randomized trials, cohort studies with control groups, and pre/post studies. Evaluations of data was based on variable-based research questions.
Results
Hydroxyurea lowered the rate of hospitizations among children with sickle cell disease and raised HbF cell percentages.
Strengths/Limitations
Limited evidence for toxicity, barriers, and guide dosing. Insufficient evidence for efficacy and safety.
Critique
Even with the use of experts, there was no appropriate design method mentioned. Identifies research needs for toxicity, guide dosing, efficacy, and safety.
Strouse, J.J., et al., (2008), Hydroxyurea for Sickle Cell Disease: A Systematic Review for Efficacy and Toxicity in Children, Pediatrics, 122:6. Doi:10.1542/peds.2008-0441,
Retrieved from http://www.pediactricsdigest.mobi/content/122/6/1332.full
Variables/Key Concepts
A synthesized literature review on the efficacy, effectiveness, and toxicity of hydroxyurea in children.
Sampling
Selected randomized trials, observational studies, and case reports that evaluated the efficacy, and toxicity of hydroxyurea in children with sickle cell disease.
Design/Method
Two reviewers abstracted data sequentially in study design, patient characteristics, and outcomes. Assessed study quality independently.
Instruments/Data Collection
Instruments were databases,...
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