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Gene Is Hereditary Material Made Research Paper

Because of the presence of an extra cysteine, a cysteine bridge is formed that causes great changes in the protein structure. ApoA1 protein does not have a cysteine dimer but cysteine dimer is formed on Apo1 Milano that causes the protein to exist as a homo or a hetro dimer with ApoAII (Futterman and Lemberg 246). It has been reported that he enhanced cholesterol removal efficiency is not because of the presence of extra cysteine. Based on the replacement of arginine by a cysteine residue, the charge of the protein is shifter towards cathode. Because of the mutation, it has been reported that the removal of cholesterol from the inner arterial walls is accelerated and much higher. The placebo trails and the clinical trials have shown that as compared to ApoA1, Apo Milano-1 can additionally clear up to 30% of atheroma from the arterial walls. The clinical trials have also shown that the plaques build inside the arterial walls are greatly reduced by Apo Milano-1 (Nissen et al. 2296). Conclusion

The synthetic protein can help in an eradiation of coronary heart disease. There are a number of claims highlighting the fact that the plaques of cholesterol from inside the walls of the arteries have been reduced to 30% in the duration of 5 weeks.
Works Cited

Futterman, G. Laurie., and Lemberg, Louis. "Apo A-I Milano." Am J. Crit Care 14 (2005): 244-247.

Nissen, E. Steven., Tsunoda, Taro., Tuzcu, Murat, E., Schoenhagen, Paul., Cooper, J. Christopher., Yasin, Muhammad., Eaton, M. Gregory., Lauer, A. Michael., Sheldon, W. Scott., Grines, L. Cindy., Halpern, Stephen., Crowe, Tim., and James Blankenship, C. James. "Effect of Recombinant ApoA-I Milano on Coronary Atherosclerosis in Patients with Acute Coronary Syndromes: A…

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Works Cited

Futterman, G. Laurie., and Lemberg, Louis. "Apo A-I Milano." Am J. Crit Care 14 (2005): 244-247.

Nissen, E. Steven., Tsunoda, Taro., Tuzcu, Murat, E., Schoenhagen, Paul., Cooper, J. Christopher., Yasin, Muhammad., Eaton, M. Gregory., Lauer, A. Michael., Sheldon, W. Scott., Grines, L. Cindy., Halpern, Stephen., Crowe, Tim., and James Blankenship, C. James. "Effect of Recombinant ApoA-I Milano on Coronary Atherosclerosis in Patients with Acute Coronary Syndromes: A Randomized Controlled Trial." JAMA 290(2003): 2292-2300.
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