1) Inflammation, Tissue Repair, and Wound Healing
Case study on a 6-year old
Six-year-old, Carlton, suffered a deep gash on his foot when playing with his mom along the beachside. His mom washed the injured foot and took him home. The next day, Carlton’s foot worsened, with the gash growing pink, inflamed, warm and painful. So his mom put gauze on the wound before taking him to their community healthcare center.
· What is the physiologic mechanism causing the wound to become red, hot, swollen, and painful? How is this different than the inflammatory response that might occur in an internal organ?
An injured tissue starts healing instantly. Tissue destruction directly injures numerous soft tissue cells which leads to metabolism alteration, with chemical mediator liberation initiating inflammatory reaction (Tissue Response to Injury, n.d). The body’s intrinsic defense mechanism mediates acute inflammatory reaction against pathogen invasion at the skin’s entry portal or systemically in case of infection of internal organs, propagating inflammation. Acute inflammatory reaction leads to the creation of a harmful microenvironment through increased leucocyte and plasma movement (particularly granulocytes) between the blood and injured tissues, for localizing and destroying specific pathogens and initiating healing. It propagates inflammation, which forms part of a complex vascular tissue reaction to all harmful stimuli (like damaged cells or invading pathogens). As such, acute inflammation represents a stereotyped primary cellular and biochemical reaction occurring only in vascularized tissues where microbial pathogens and other harmful stimuli cause cell invasion, injury, or death. Further, its mediators include a torrent of biomedical occurrences furthering and maturing acute inflammatory reaction involving the immune and...
References
Berg, R.H. (2014). Communicable Medical Diseases: A Holistic and Social Medicine Perspective for Healthcare Providers. Balboa Pr.
Bickley, L., & Szilagyi, P. G. (2012). Bates' guide to physical examination and history-taking. Lippincott Williams & Wilkins.
Lane, S. S. (2007). New thinking in the treatment of postoperative inflammation. Retrieved May 14, 2018, from https://www.healio.com/optometry/cornea-external-disease/news/online/{8f41d77a-e214-4109-89b9-5f172d41529a}/new-thinking-in-the-treatment-of-postoperative-inflammation
Muhrer, J. C. (2014). The importance of the history and physical in diagnosis. The Nurse Practitioner, 39(4), 30-35.
Tissue Response to Injury (n.d.) Retrieved 14 May 14, 2018 from http://highered.mheducation.com/sites/dl/free/0078022649/998035/Prentice15e_Chap10.pdf
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