The second option is worth considering for patients with large or multiple liver lesions because this route results in delivery of a higher dose of chemotherapy to the liver metastases. The underlying principle is that liver metastases derive their blood supply primarily through the hepatic arterial circulation, whereas normal liver derives most of its blood supply through the portal vein. The major adverse effect of intraarterial FUDR is sclerosing cholangitis, which may be quite severe and may necessitate discontinuation of therapy.
Studies have demonstrated a survival advantage for patients with Dukes stage C. colon cancer who receive adjuvant chemotherapy. The 5-FU-based therapy has been administered in the past according to several schedules, including continuous infusion daily for 5 days every 4 weeks (Mayo Clinic regimen) and weekly for 6 weeks with 2 weeks off (Roswell Park regimen).
In terms of patient survival, no study has demonstrated the superiority of daily therapy for 5 days every 4 weeks over weekly therapy for 6 weeks or any other schedule. Thus, the regimens that can be administered on an outpatient basis (weekly for 6 wk with 2 wk off or daily for 5 days every 4 wk) are the most popular and are widely considered to be essentially equivalent.
The classic surgical procedure for colon cancer is anterior resection that involves a "no touch" isolation technique. The abdomen is explored to determine whether the tumor is resectable, and resection is performed segmentally with end-to-end anastomosis. Total colonic resection is performed for patients with familial polyposis and multiple colonic polyps. Although sulindac appears to influence the morphological appearance of polyps in patients with familial adenomatous polyposis, inducing apparent regression at a dose of 200 mg, it does not influence the progression of polyps toward a malignant pattern.
The technology exists to use laparoscopic techniques to achieve colon resection. A recent study reported favorable results with 5 years of follow-up. Sphincter replacement by electrically stimulated skeletal muscle neosphincter and artificial anal sphincter provide a continence option for patients with end-stage fecal incontinence and those requiring abdominoperineal resection.
Partial hepatectomy for colon cancer metastases limited to the liver is a therapeutic option...
Who.int/mediacentre/factsheets/fs297/en/ Colon Cancer." (2008). Mayo clinic.com. Retrieved on February 27, 2008 at http://www.mayoclinic.com/health/colon-cancer/DS00035 Colon Cancer Treatment." (2007). National Cancer Institute. Retrieved on February 27, 2008 at http://www.cancer.gov/cancertopics/pdq/treatment/colon/patient Lee, Dennis. "Colon Cancer (Colorectal Cancer)" (2007). Medicine net.com. Retrieved on February 27, 2008 at http://www.medicinenet.com/colon_cancer/article.htm Myers, Donna. (2008). "Overview of Colon Cancer Symptoms." About.com: Health. Retrieved on February 27, 2008 at http://coloncancer.about.com/od/cancerprevention/a/Cancer_Symptoms.htm The colon is part of the body's digestive system, which consists of the esophagus, stomach,
Colon Health Statement of the theme risk factors prevention Diet Exercise Dietary supplementation No one really wants to talk about the subject of their colons. We all started out life with one, most of ours are working very well as we sit here today. But though speaking about the colon seems to be dirty or disagreeable, it is very important that we all pay attention to the colon. Colorectal cancer is the second most common cancer death
In the daily diet; (5) Include cruciferous vegetables in the diet. (Brussels sprouts, kohlrabi and cauliflower); (6) Consume alcoholic beverages only moderately; and (7) Only moderately consume salt-cured, smoked and nitrate cured foods. (American Cancer Society, 1984, pp. 122-123) What little was understood about nutrition as it relates to cancer rates is summed up in the following specific food categories by the American Cancer Society in its 1984 report: Food
This is related to bronchitis, asthma and long-term conditions such as lung cancer and bladder cancer (Robinson, 2009). It is estimated that the chances of getting bladder cancer is high for ex-smokers and passive smokers even after thirty years later. This brings us to the question of management of bladder cancer for current and ex-smokers as well as passive smokers. The management of bladder cancer is a three-pronged approach that involves
Health Care (PHC) and Colorectal Cancer Authorities around the world have expressed the need for development of an incorporated health care system with augmented emphasis on primary health care, and integration of principles and practices of health promotion. Primary health can be defined as the care provided at the first point of contact with the health care system, the point at which health services are assembled and synchronized to promote
Medicine Yogurt Consumption Lowers Colorectal Cancer Risk Colorectal cancer is the third most common cancer in the world, with over a million people developing the disease each year (reviewed by Touvier et al., 2011; Aune et al., 2011; Pala et al., 2011; van Duijnhoven et al., 2009). The worldwide distribution of this disease is uneven though, with developed economies like North American and Western Europe generally having the highest prevalence rates.
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