Body Surface Area-Based Dosing
Flat- Fixed Dosing vs. Body Surface Area-Based Dosing of Anticancer Drugs in Adults: Does It Make a Difference?
Explain Body-Surface-Area-based dosage
Body Surface Area-based dosing is a critical formula applicable in the calculation of drug doses in the case of two types of patient groups. These two types of patient groups include cancer patient under the aspect of chemotherapy and pediatric patients. DuBois and DuBois derived the formula in the case of 1916 in a research which nine individuals took part (DuBois & DuBois, 1916). It is ideal to note that the average or normal adults have a BSA of about 1.73 m2. It refers to the current standard of care applicable in the determination of the dose of various chemotherapy drugs in relation to the body surface area of the patients on chemotherapy drugs. It is critical to understand that BSA-based dosing is a 'one size fits all' approach in relation to calculating drug dose with reference to patients on chemotherapy drugs. The mathematical formula utilizes the height and weight of the patient in the calculation of the drug dose for chemotherapy and pediatric drugs.
It is critical to note that BSA-based dosing approach is ineffective in addressing dosage issues for chemotherapy and pediatric drugs. According to various research studies, BSA-based dosing approach is ineffective in relation to realizing the optimal or right systematic concentration of the drugs with the aim of generating best treatment results (De Jongh et al., 2001). Since its development in 1916, various research studies continue to illustrate how individuals absorb and process substances in the form of drugs and food into their systems. This is because of the number of factors influencing the rate of drug clearance. The rate of drug clearance varies from one person to another with approximately 30-fold difference. For instance, the functioning of an organ as well as the state of the disease will have massive impact on the body and its ability to process the chemotherapy drugs. In addition, it is essential to note that more advanced cancer has the ability to absorb more drugs in comparison to the smaller...
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The large intestine begins near the lower coils of the small intestines but then ascends up the right side and bend back over the top of the highest loop of the small intestine. Several layers of muscle and sinewy tissue wrap around the area housing the internal organs (Iazzetti & Rigutti, 2007). The other organs located in the major body cavity include the bladder, gall bladder, and pancreas. In addition,
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..). Because of these problems, employees working under these conditions also suffer from more vehicle related accidents. In particular, individuals working evening and night shifts are more likely to fall asleep on their way home after work. Statistics demonstrate that "...41% of extended hours employees reported nodding off while driving compared with 28% of day workers" (Extended hours...). What this effectively suggests is that firefighters and first responders face a
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Human Health and Disease How could the information learned about a disease's epidemiology be used to protect public health? What kind of epidemiological information would a public health official want to know about this disease? What actions might they take based on this information? The epidemiology will look at factors such as demographics, causes, patterns and the impact the disease is having. This is used to determine the symptoms, educate the general
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