Atherosclerosis
Atherosclerosis is one of the major causes of premature disability and death in developed nations. It is estimated that this condition will become the leading cause of total disease burden in the near future because its development is fueled by multiple generalized or systemic risk factors. Rao & Kiranmayi1 note that the condition is a dynamic and progressive disease that is brought about by an injury to endothelium and its associated inflammatory response. Since atherosclerosis is likely to become the leading cause of disease burden in developed countries, an understanding of the condition is essential to enhance prevention. Insights into the biochemical basis and clinical implications of atherosclerosis are essential to promote a better understanding and management of the condition.
Biochemical Basis and Clinical Implications of Atherosclerosis
Atherosclerosis is a disease brought by various causes and is regarded as the primary underlying cause of cardiovascular diseases and cerebrovascular accidents. The biochemical mechanisms underlying this condition involve lipid accumulation and immune activation that take place in the vascular wall. Alfarisi, Mohamed & Ibrahim2 state that inflammation, genetic predisposition, and oxidation are the major factors contributing to the development of this condition. Immune activation and lipid accumulation are processes that are highly regulated by several specialized lipid and protein mediators. These mediators either promote the development of atherosclerosis by stimulating inflammation or inducing resolution of inflammation, which makes them anti-atherosclerosis. Blood vessels play an important role in the development of atherosclerosis as they are generally exposed to several...
References
1. Rao PS, Kiranmayi, VS. Biochemical mechanisms underlying atherogenesis. The J. of Clin and Sci. Res. 2012;01(01):24-34.
2. Alfarisi HAH, Mohamed ZBH, Ibrahim MB. Basic pathogenic mechanisms of atherosclerosis. Egyptian J. of Basic and App. Sci. 2020;7(1):116-125.
3. Kwak BR, Back M, Bochaton-Piallat, M, et al. Biomechanical factors in atherosclerosis: Mechanisms and clinical implications. European Heart J. 2014;35(43):3013-3020.
The idea that animal fat consumption causes heart disease is perhaps the most controversial component of the standard preventative advice given to reduce heart disease. This association is based upon the research of Ancel Keyes, who compared heart disease rates in the United States, Canada, Australia, England, Italy, and Japan and found that lower rates of heart disease were manifested in countries with less saturated fat consumption. However, there are
Though this work focuses specifically on the risk factors of atherosclerosis for RA patients and how to better identify them prior to clinical presentation of atherosclerosis the work is also insightful in that it builds a case for the connection between RA clinical presentations and atherosclerosis, in general. To move forward from this progressive idea is the fact that research has indicated that there is an even greater connection
Pathogenesis of Atherosclerosis Artery diseases are of immense concern to medical researchers due to the cause and effect relationship shared with heart disease and cardiovascular mortality. Atherosclerosis is one of the diseases earning such focus from researchers because of its multifactorial nature, and its period of development which typically occurs years before clinical symptoms are apparent. Atherosclerosis is a disease of the arterial wall that promotes several common causes of cardiovascular
Atherosclerosis Factors That Influence Disease Factors that influence disease: Atherosclerosis and gender Atherosclerosis is often colloquially referred to as the 'hardening of the arteries.' In a patient with atherosclerosis, plaque builds up on the patient's blood vessels which are required to "carry oxygen-rich blood to your heart and other parts of your body" (What is atherosclerosis, 2013, NIH). Impeding this flow can have severe health effects, including coronary and cardioid heart disease as
Atherosclerosis and the various complications associated with this disease, especially towards its final stages, may causes disability and death within Western societies. Although advancement of atherosclerosis is a slow process, beginning in childhood, remaining asymptomatic for several decades, complication like myocardial infarction, peripheral ischemia, or stroke happening later on in life. Some recognized risk factors towards the development of the illness include diabetes, hypertension, obesity, dyslipidaemia, smoking, sedentary lifestyle, and
Our semester plans gives you unlimited, unrestricted access to our entire library of resources —writing tools, guides, example essays, tutorials, class notes, and more.
Get Started Now